ASSOCIATION OF CELIAC DISEASE WITH MULTIPLE SCLEROSIS

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ABOU ALFAZLI R.; MIRBAGHERI SEYED AMIR; RABANI ANARI M.

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Journal: Tehran University Medical Journal Year:2007 | Volume:65 | Issue:7 Page(s): 37-42

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Information Journal Paper

Title

ASSOCIATION OF CELIAC DISEASE WITH MULTIPLE SCLEROSIS

Author(s)

ABOU ALFAZLI R. | MIRBAGHERI SEYED AMIR | RABANI ANARI M. | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ3

CELIAC DISEASEQ3

ANTI-GLIADINQ3

ANTI-ENDOMYSIALQ3

PROLACTINQ3

DUODENAL BIOPSYQ3

Abstract

Background: MULTIPLE SCLEROSIS (MS) and the gluten intolerance disease, CELIAC DISEASE, (CD) are immune-mediated diseases. Better testing for antibodies associated with CD, including ANTI-GLIADIN antibody [AGA], as well as ANTI-ENDOMYSIAL and anti-tissue transglutaminase antibodies, has improved the diagnosis of CD. Certain neurologic conditions have a reported association with CD. Previous researchers have investigated the role of a gluten-free diet in the treatment of MS and found no benefits. Here, we investigate the possible immunological association of CD with MS.Methods: Using ELISA, we estimated serum IgG and IgA ANTI-GLIADIN and IgA antiendomysial antibodies in 34 MS patients, who were new or previous cases without immunosuppressant treatment for at least the last six months. The mean age was 29.6 years (range 15-46 years), with 30 patients relapsing-remitting, and four secondaryprogressive MS. Thirty-four random anonymous blood donors were used as serologic controls (mean age 31.4 years, range 19-50 years). The individuals in both groups with elevated AGA (IgG or IgA) or ANTI-ENDOMYSIAL antibody (IgA) underwent DUODENAL BIOPSY.Results: In the MS group, high levels of IgG AGA were found in 5.9% of the subjects, and 5.9% had elevated IgA AGA. In the controls, elevated IgG AGA was detected in 5.9% of the subjects and IgA AGA in 2.9% (p=0.051 and 0.48, respectively). For IgG and IgA AGA levels, no significant differences were found between the patient and control groups. IgA ANTI-ENDOMYSIAL antibodies were not found in either group. Upon biopsy, the specific pathological features of celiac were absent.Conclusion: The same number of MS patients and controls had high levels of AGA, with normal levels of IgA ANTI-ENDOMYSIAL antibodies, which is more specific for CD, while the GI biopsies from both groups were not specific for CD. Therefore, AGA levels in any neurologic case should be interpreted with caution. The present study showed no association between MS and CD.

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APA: Copy

ABOU ALFAZLI, R., MIRBAGHERI, SEYED AMIR, & RABANI ANARI, M.. (2007). ASSOCIATION OF CELIAC DISEASE WITH MULTIPLE SCLEROSIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 65(7), 37-42. SID. https://sid.ir/paper/38646/en

Vancouver: Copy

ABOU ALFAZLI R., MIRBAGHERI SEYED AMIR, RABANI ANARI M.. ASSOCIATION OF CELIAC DISEASE WITH MULTIPLE SCLEROSIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;65(7):37-42. Available from: https://sid.ir/paper/38646/en

IEEE: Copy

R. ABOU ALFAZLI, SEYED AMIR MIRBAGHERI, and M. RABANI ANARI, “ASSOCIATION OF CELIAC DISEASE WITH MULTIPLE SCLEROSIS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 65, no. 7, pp. 37–42, 2007, [Online]. Available: https://sid.ir/paper/38646/en

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