Relationship of 536C/T Tissue Factor Pathway Inhibitor Gene and Alu_I/D Tissue-type Plasminogen Activator Gene Polymorphisms with Recurrent Pregnancy Loss in Iranian Azeri Women

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AMERI Z.; MEHMANNAVAZ Y.

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Journal: Pathobiology Research Year:2018 | Volume:21 | Issue:3 Page(s): 147-152

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Information Journal Paper

Title

Relationship of 536C/T Tissue Factor Pathway Inhibitor Gene and Alu_I/D Tissue-type Plasminogen Activator Gene Polymorphisms with Recurrent Pregnancy Loss in Iranian Azeri Women

Author(s)

AMERI Z. | MEHMANNAVAZ Y. | Issue Writer Certificate

Keywords

Abortion HabitualQ2

ThrombosisQ2

Tissue factor pathway inhibitorQ1

Tissue plasminogen activatorQ1

Genetic PolymorphismQ1

Abstract

Aims Tissue factor pathway inhibitor (TFPI) and Tissue plasminogen activator (tPA) deficiency would cause an increase in the viscosity of fibrinogen and low digestion of blood clot, respectively, which are among the dangerous factors responsible for the increase in Thrombosis. Although there are reports, indicating the relationship of vein Thrombosis and recurrent pregnancy loss (RPL), the effect of polymorphisms connected with Thrombosis on the risk of increasing RPL has remained unclear. Thus, the aim of this study was to evaluate the relationship of 536C/T Tissue factor pathway inhibitor gene and Alu_I/D tissue-type plasminogen activator gene polymorphisms with recurrent pregnancy loss in Iranian Azeri women. Instruments & Methods The present case-control study was conducted in Azari women with RPL and healthy women during 2015-2016. Ninety-five women with RPL were selected by simple random sampling sampling method, and 95 healthy women were selected and assessed, using Multiplex ARMS-PCR method. The data were analyzed by SAS 9. 2 software, using logistic regression and Chi-square test. Findings Among two genes polymorphisms, only tPA polymorphism was significantly related with the increase in RPL, such that allele I in this polymorphism caused more than two-folded odds ratio of RPL compared to allele D. Women between the ages of 25 and 35 years significantly showed the highest odds ratio of RPL. Conclusion Alu_I/D tissue-type plasminogen activator gene polymorphism is related with an increased risk of RPL in Azeri women in northwestern Iran, but 536C/T Tissue factor pathway inhibitor gene does not show such a relationship.

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APA: Copy

AMERI, Z., & MEHMANNAVAZ, Y.. (2018). Relationship of 536C/T Tissue Factor Pathway Inhibitor Gene and Alu_I/D Tissue-type Plasminogen Activator Gene Polymorphisms with Recurrent Pregnancy Loss in Iranian Azeri Women. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 21(3 ), 147-152. SID. https://sid.ir/paper/386484/en

Vancouver: Copy

AMERI Z., MEHMANNAVAZ Y.. Relationship of 536C/T Tissue Factor Pathway Inhibitor Gene and Alu_I/D Tissue-type Plasminogen Activator Gene Polymorphisms with Recurrent Pregnancy Loss in Iranian Azeri Women. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2018;21(3 ):147-152. Available from: https://sid.ir/paper/386484/en

IEEE: Copy

Z. AMERI, and Y. MEHMANNAVAZ, “Relationship of 536C/T Tissue Factor Pathway Inhibitor Gene and Alu_I/D Tissue-type Plasminogen Activator Gene Polymorphisms with Recurrent Pregnancy Loss in Iranian Azeri Women,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 21, no. 3 , pp. 147–152, 2018, [Online]. Available: https://sid.ir/paper/386484/en

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