A COMPARATIVE STUDY OF CEFIXIME AND CHLORAMPHENICOLE FOR TREATMENT OF PATIENTS WITH TYPHOID FEVER

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SAMAR G.; HAJI ABD ALBAGHI MAHBOUBEH; AHMADINEZHAD Z.; EMADI KOUCHAK H.; EMADI J.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2001 | Volume:59 | Issue:3 Page(s): 18-25

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Title

A COMPARATIVE STUDY OF CEFIXIME AND CHLORAMPHENICOLE FOR TREATMENT OF PATIENTS WITH TYPHOID FEVER

Author(s)

Keywords

CEFIXIMEQ4

TYPHOID FEVERQ4

CHLORAMPHENICOLEQ4

Abstract

Typhoid fever is an endemic disease in Iran and other developing countries. This disease has gradually become resistant to the first line of drugs, and because of this resistancy we have studied a new alternative drug (CEFIXIME) on TYPHOID FEVER patients and compared it’s effectiveness with chloramphenicol. For this purpose, by a randomized clinical trial in Emam Khomeini hospital between 1995-2000, we allocated 44 uncomplicated patient with established TYPHOID FEVER (positive blood or bone marrow culture) and by random selection, 24 patient were given CEFIXIME (400 mg PO bid) and 20 patient received chloramphenicol (500 mg po Q6h). The duration of therapy were 10 and 14 days for chloramphenicol and CEFIXIME group respectively. Median fever clearance times were 5±1.9 for CEFIXIME and 3.8±1.2 days for chloramphenicol treated patients, but for improvement in other clinical and laboratory findings, there were but any significant difference. Bacteriologic and clinical cure rate for CEFIXIME was 100 and 92 percents respectively. Though, even CEFIXIME like other betalactam drugs is slow in helping the fever disappearance but our study suggests that oral CEFIXIME is effective and can be used as an alternate treatment of TYPHOID FEVER.

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APA: Copy

SAMAR, G., HAJI ABD ALBAGHI, MAHBOUBEH, AHMADINEZHAD, Z., EMADI KOUCHAK, H., & EMADI, J.. (2001). A COMPARATIVE STUDY OF CEFIXIME AND CHLORAMPHENICOLE FOR TREATMENT OF PATIENTS WITH TYPHOID FEVER. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 59(3), 18-25. SID. https://sid.ir/paper/38661/en

Vancouver: Copy

SAMAR G., HAJI ABD ALBAGHI MAHBOUBEH, AHMADINEZHAD Z., EMADI KOUCHAK H., EMADI J.. A COMPARATIVE STUDY OF CEFIXIME AND CHLORAMPHENICOLE FOR TREATMENT OF PATIENTS WITH TYPHOID FEVER. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2001;59(3):18-25. Available from: https://sid.ir/paper/38661/en

IEEE: Copy

G. SAMAR, MAHBOUBEH HAJI ABD ALBAGHI, Z. AHMADINEZHAD, H. EMADI KOUCHAK, and J. EMADI, “A COMPARATIVE STUDY OF CEFIXIME AND CHLORAMPHENICOLE FOR TREATMENT OF PATIENTS WITH TYPHOID FEVER,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 59, no. 3, pp. 18–25, 2001, [Online]. Available: https://sid.ir/paper/38661/en

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