ALPHA2- ADRENOCEPTORS AND 5-HT2 SEROTONERGIC RECEPTORS ANTAGONIST EFFECTS ON AMITRYPTILINE-
INDUCED ANALGESIA IN RAT

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PARVINI S.; BAKHTIARIAN A.; TABARESTANI S.; PARTOAZAR A.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:63 | Issue:9 Page(s): 703-709

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Title

ALPHA2- ADRENOCEPTORS AND 5-HT2 SEROTONERGIC RECEPTORS ANTAGONIST EFFECTS ON AMITRYPTILINE- INDUCED ANALGESIA IN RAT

Author(s)

PARVINI S. | BAKHTIARIAN A. | TABARESTANI S. | PARTOAZAR A. | Issue Writer Certificate

Keywords

AMITRYPTILINEQ4

TRICYCLIC ANTIDEPRESSANTSQ3

ANALGESICACTIONQ4

ALPHA- 2 ADRENOCEPTORSQ4

5-HT2 SEROTONERGIC RECEPTORSQ4

Abstract

Background: AMITRYPTILINE and other TRICYCLIC ANTIDEPRESSANTS are widely used in chronic pain states in humans. The clear expression of local analgesic action with antidepressants raises the possibility that this class of agents could be given topically and may be useful as peripherally acting analgesics in humans. Methods and Materials: In this study, effect of alpha-2 adrenoceptors and 5-HT2 SEROTONERGIC RECEPTORS antagonist on the analgesia induced by AMITRYPTILINE in rat was investigated. Subcutaneous injection of different doses of AMITRYPTILINE (4,8,16 mg/kg) induces dose-related analgesia in rat. Results: The alpha-2 adrenoceptors antagonist, yohimbine (2mg/kg) reduced the response induced by AMITRYPTILINE but 5-HT2 SEROTONERGIC RECEPTORS antagonist, ketanserin (lmg/kg) increased the response induced by AMITRYPTILINE. Conclusions: It seems that Ketanserin increased the pain threshold. It may be concluded that AMITRYPTILINE-induced analgesia is through alpha2- adrenoceptors mechanism.

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APA: Copy

PARVINI, S., BAKHTIARIAN, A., TABARESTANI, S., & PARTOAZAR, A.. (2005). ALPHA2- ADRENOCEPTORS AND 5-HT2 SEROTONERGIC RECEPTORS ANTAGONIST EFFECTS ON AMITRYPTILINE- INDUCED ANALGESIA IN RAT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 63(9), 703-709. SID. https://sid.ir/paper/38680/en

Vancouver: Copy

PARVINI S., BAKHTIARIAN A., TABARESTANI S., PARTOAZAR A.. ALPHA2- ADRENOCEPTORS AND 5-HT2 SEROTONERGIC RECEPTORS ANTAGONIST EFFECTS ON AMITRYPTILINE- INDUCED ANALGESIA IN RAT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;63(9):703-709. Available from: https://sid.ir/paper/38680/en

IEEE: Copy

S. PARVINI, A. BAKHTIARIAN, S. TABARESTANI, and A. PARTOAZAR, “ALPHA2- ADRENOCEPTORS AND 5-HT2 SEROTONERGIC RECEPTORS ANTAGONIST EFFECTS ON AMITRYPTILINE- INDUCED ANALGESIA IN RAT,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 63, no. 9, pp. 703–709, 2005, [Online]. Available: https://sid.ir/paper/38680/en

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