High intensity interval training increases the expression of hippocampus BDNF gene and decreases the serum tnf-a in Diabetic Rat

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Abbasi Shaqhayegh; KHALEDI NEDA; ASKARI HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Tabriz University of Medical Sciences Year:2020 | Volume:42 | Issue:5 Page(s): 591-600

Download Full-Text

Persian Verion

View:

545

Download:

Cites:

Information Journal Paper

Title

High intensity interval training increases the expression of hippocampus BDNF gene and decreases the serum tnf-a in Diabetic Rat

Author(s)

Abbasi Shaqhayegh | KHALEDI NEDA | ASKARI HOSSEIN | Issue Writer Certificate

Keywords

High Intensity Interval TrainingQ1

TNF-αQ1

Brain-Drieved Neurotrophic FactorQ1

Time To ExhaustionQ1

Abstract

Background: Diabetics have many disabilities, including neuronal damege hippocampus, and BDNF is an effective factor in this field. This factor has the most impact on the hippocampus, also TNF-α is an inflammatory factor that increases in diabetes, the purpose of this study was to investigate the effect of 6 weeks of High Intensity Interval Training on the gene expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of male Wistar rats. Methods: For this study, 48 male Wistar rats (4 weeks old) with 150± 10 g weight were categorized in 4 groups of: diabetic rats (n= 12), exercise diabetic (n= 12), control (n= 12) and exercise control (n= 12). For induction of diabetes, peritoneal injection of STZ solution (50 mg/kg) was used. After a week of familiarization with the environment and practice, High Intensity Interval Training protocol consisted of 3 days of training per week for 6 weeks with 50% to 110% of maximum oxygen consumption was performed. 24 hours after the completion of the exercise, the functional test was taken and the animals were autopsy 48 hours after the functional test. Finally, BDNF gene expression was evaluated using Real Time PCR technique. Results: Regarding the results, it was found that the High Intensity Interval Training intensified the expression of the BDNF gene and decreased the expression of the TNF-α protein. also The weight gain of the hippocampus has been observed along with increased expression of BDNF gene in the diabetic High Intensity Interval Training group. Conclusion: Exercise can help prevent hippocampus tissue loss, and also prevent memory damage that caused by diabetes. Also, High Intensity Interval Training are effective in maintaining the physical fitness of diabetics, therefore High Intensity Interval Training are recommended for improvement in the physical condition and life of diabetics.

Cites

اثر تمرینات تناوبی با شدت زیاد بر اختلالات شناختی و حافظه ناشی از چاقی و دیابت: مطالعه مروری نظام مند (مقاله مروری نظام مند)

References

Cite

APA: Copy

Abbasi, Shaqhayegh, KHALEDI, NEDA, & ASKARI, HOSSEIN. (2020). High intensity interval training increases the expression of hippocampus BDNF gene and decreases the serum tnf-a in Diabetic Rat. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(5 ), 591-600. SID. https://sid.ir/paper/387495/en

Vancouver: Copy

Abbasi Shaqhayegh, KHALEDI NEDA, ASKARI HOSSEIN. High intensity interval training increases the expression of hippocampus BDNF gene and decreases the serum tnf-a in Diabetic Rat. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;42(5 ):591-600. Available from: https://sid.ir/paper/387495/en

IEEE: Copy

Shaqhayegh Abbasi, NEDA KHALEDI, and HOSSEIN ASKARI, “High intensity interval training increases the expression of hippocampus BDNF gene and decreases the serum tnf-a in Diabetic Rat,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 5 , pp. 591–600, 2020, [Online]. Available: https://sid.ir/paper/387495/en

Related Journal Papers