DETERMINATION OF APPROPRIATE ANTIBIOTIC IN BACTERIAL MENINGITIS OF CHILDREN BASED ON MIC

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NOORBAKHSH S.; SIADATI S.A.; RIMAZ S.; MAMISHI S.; HAGHI ASHTIANI T.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:63 | Issue:1 Page(s): 68-76

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Title

DETERMINATION OF APPROPRIATE ANTIBIOTIC IN BACTERIAL MENINGITIS OF CHILDREN BASED ON MIC

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Keywords

BACTERIAL MENINGITISQ4

MICROBIAL RESISTANCEQ4

ANTIBIOTICS MICQ4

Abstract

Background: BACTERIAL MENINGITIS is one of the most serious infections in infants and children. Three organisms include S.Pneumo;N.mening;H.Influ are the most common cause of meningitis in children between 2M-14y age. Etest is a new method for determination the MIC of some antimicrobial drugs in agarose .This method is useful for some organisms like as S .Pneumo; N.mening; H.Influ;sensitive Streptococcus and anaerobic ;aerobic gram negative.Materials and Methods: In this descriptive cross sectional study; In 57 suspected meningitis children ; organisms isolated from blood; CSF or other sterile boy fluid after culturing and antibiogram;. .MIC of someorganisms detected by Etest method.Results: Streptococcuswas the most prevalent ( 70%) and S.pneumon( 90% of all Streptococcus); H.infl 2%;N.mening 4%and L.monocyt 6%(more than expected);Gram negative (Ecoli; Klebsiella; entrobacter and psudomona) 18%. There was significant difference (P =0.01)in type of organisms between age groups. S.pneumonia was more frequent in children > 2 year ;N.meningitis in>4yr old .Site of isolation :blood; CSF (35.8*;28.3%)other sterile site 18.4%;concomitant positive culture in two site:17%.Mean age in Streptococcus was significantly different with Listeria (p=0.05); N.meningitis (p=0.04);H.influ (p=0.04);.but no difference with Staphylococcus; Klebsiella and E.coli Two type of H.inf were sensitive to Ampici or chloram ;both of them were sensitive to ceftiaxon. GBS were sensitive to PNC or AmpiciStrep.nonAnonBnon-Cotrimoxazol>32mic/ml /PNC >256mic/ml/ Vanco>256mic/ml Strep.D:Cotrimoxazol>0.062mg/ml/ /PNC >0.016mic/ml/Imipenem>0.032mic/ml.Strep Pneumonia:All fo them were sensitive except 3 cases/Cotrimoxazol>2ic/ml /PNC =0.01mic/ml/Vanco>0.125mic/ mVanco>0. 25mic/ ml/.Cotrimoxazol>2ic/ml / PNC =0.01mg/mlVanco>0.125mic/ ml / Cotrimoxazol>2mic/ml /MIC-PNC >0.016mic/ml Therefore high dose of PNC is adequate for S.pneu ;because of Interm resistance to PNCAll 3 N.menin were sensitive to PNC;Chlora;Ceftria and vancoResistant to all drugs and high MIC for cefotaxime;CIPRO>32mic/ml. E coli: Pseudomona Aerogenosa::Ceftriaxon>256mic/ml/ /Genta>0.038mg/mlImipenem>32mic/ml.Klebsiella; only Sensitive to CiproStaph .Aureous:Sensitive to Clinda;Cipro;Chlora;Resistant toCeft;PNCand CotriConclusion: Most type of N.meningitidis;H.inf and S.pneumonia were sensitive to many drugs. Only minority of them were resistant to Ampicillin but sensitive to chloramphenicol and vice versa. limited number of pneumococcal resistance to penicillin is medium resistance( MIC:0.1-1) .we can treat this resistant type by increasing of penicillin dosage .The others were sensitive to all drugs. Therefore ampicillin and chloramphenicol are the drug of choice in empiric treatment of BACTERIAL MENINGITIS after neonatal period.

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APA: Copy

NOORBAKHSH, S., SIADATI, S.A., RIMAZ, S., MAMISHI, S., & HAGHI ASHTIANI, T.. (2005). DETERMINATION OF APPROPRIATE ANTIBIOTIC IN BACTERIAL MENINGITIS OF CHILDREN BASED ON MIC. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 63(1), 68-76. SID. https://sid.ir/paper/38752/en

Vancouver: Copy

NOORBAKHSH S., SIADATI S.A., RIMAZ S., MAMISHI S., HAGHI ASHTIANI T.. DETERMINATION OF APPROPRIATE ANTIBIOTIC IN BACTERIAL MENINGITIS OF CHILDREN BASED ON MIC. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;63(1):68-76. Available from: https://sid.ir/paper/38752/en

IEEE: Copy

S. NOORBAKHSH, S.A. SIADATI, S. RIMAZ, S. MAMISHI, and T. HAGHI ASHTIANI, “DETERMINATION OF APPROPRIATE ANTIBIOTIC IN BACTERIAL MENINGITIS OF CHILDREN BASED ON MIC,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 63, no. 1, pp. 68–76, 2005, [Online]. Available: https://sid.ir/paper/38752/en

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