EFFICACY OF SINGLE-DOSE METHOTREXATE IN THE TREATMENT OF ECTOPIC PREGNANCY: A CLINICAL TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BEHNAMFAR F.; YAZDANI SH.; SAKHAEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2007 | Volume:65 | Issue:8 Page(s): 35-39

Download Full-Text

Persian Verion

View:

5,915

Download:

Cites:

Information Journal Paper

Title

EFFICACY OF SINGLE-DOSE METHOTREXATE IN THE TREATMENT OF ECTOPIC PREGNANCY: A CLINICAL TRIAL

Author(s)

BEHNAMFAR F. | YAZDANI SH. | SAKHAEI M. | Issue Writer Certificate

Keywords

ECTOPIC PREGNANCYQ3

METHOTREXATEQ3

CONSERVATIVE MANAGEMENTQ3

Abstract

Background: The use of serial quantitative beta-human chorionic gonadotropin (β–HCG) with transvaginal ultrasound to enhance early diagnosis of ECTOPIC PREGNANCY (EP) improves options for conservative treatment with METHOTREXATE (MTX). The aim of this study was to evaluate the outcome of unruptured EP treated with a single dose of intramuscular MTX injection.Methods: This clinical trial included 41 EP patients with specific inclusion criteria for medical treatment. For each patient, MTX (50 mg/ml) was administered intramuscularly and a repeat dose was given if the weekly decrease in the level of β–HCG was less than 15%. The therapy was considered successful if the level of β–HCG fell below 10 mIU/cc without surgical intervention.Results: Overall, 78% of the patients were successfully treated, among whom 18.7% received second doses of MTX. Of the patients who were successfully treated, 60% presented with vaginal bleeding without pelvic pain; however, of those patients in whom the treatment failed, 88% presented with pelvic pain together with vaginal bleeding. Furthermore, the presence of free peritoneal fluid on vaginal ultrasound was a significant predictor of treatment failure (p<0.005). There was no relation between the women’s age, gravidity or parity, the size of the conceptus, gestational age, pretreatment serum β–HCG titer, endometrial thickness on vaginal ultrasound and the efficacy of treatment.Conclusions: With a reasonably high success rate, we found systemic single-dose MTX treatment to be a safe, conservative therapy for EP. However, when free peritoneal fluid is noted upon transvaginal ultrasound or when the patient presents with pain, the threshold for surgical intervention may be lower.

Cites

PREDICTORS OF SINGLE-DOSE METHOTREXATE TREATMENT FAILURE IN ECTOPIC PREGNANCY

References

No record.

Cite

APA: Copy

BEHNAMFAR, F., YAZDANI, SH., & SAKHAEI, M.. (2007). EFFICACY OF SINGLE-DOSE METHOTREXATE IN THE TREATMENT OF ECTOPIC PREGNANCY: A CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 65(8), 35-39. SID. https://sid.ir/paper/38847/en

Vancouver: Copy

BEHNAMFAR F., YAZDANI SH., SAKHAEI M.. EFFICACY OF SINGLE-DOSE METHOTREXATE IN THE TREATMENT OF ECTOPIC PREGNANCY: A CLINICAL TRIAL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2007;65(8):35-39. Available from: https://sid.ir/paper/38847/en

IEEE: Copy

F. BEHNAMFAR, SH. YAZDANI, and M. SAKHAEI, “EFFICACY OF SINGLE-DOSE METHOTREXATE IN THE TREATMENT OF ECTOPIC PREGNANCY: A CLINICAL TRIAL,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 65, no. 8, pp. 35–39, 2007, [Online]. Available: https://sid.ir/paper/38847/en

Related Journal Papers