Stereological Evaluation of Cell Proliferation following Intrarenal Injection of Platelet-rich Plasma in Gentamicin-treated Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAFI A.; MOGHADAM A.; MOGHADAM N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ardabil University of Medical Sciences Year:2020 | Volume:19 | Issue:4 Page(s): 418-429

Download Full-Text

Persian Verion

View:

307

Download:

Cites:

Information Journal Paper

Title

Stereological Evaluation of Cell Proliferation following Intrarenal Injection of Platelet-rich Plasma in Gentamicin-treated Rats

Author(s)

MAFI A. | MOGHADAM A. | MOGHADAM N. | Issue Writer Certificate

Keywords

StereologyQ3

Platelet rich PlasmaQ1

GentamicinQ3

ProliferationQ1

Abstract

Background & objectives: Nephrotoxicity is the most important side effect of Gentamicin and is a concern in clinical situations. There are no therapeutic tools to prevent or palliate nephrotoxicity. Platelet-rich plasma (PRP) as a source of growth factors can be considered as a therapeutic tool. Therefore, the aim of this study was to investigate the effects of PRP on Proliferation of epithelial cells of convoluted tubules in Gentamicin-treated rat model by stereological method. Methods: 28 male rats (200-300g) were divided into four groups, each group containing 7 animals: control, patient without treatment, sham and experimental groups. Gentamicin was injected intraperitoneally (80mg/kg/daily) for 8 days. 24 hours after the last injection, blood samples were collected to assess the serum levels of blood urea nitrogen and creatinine. The sham and experimental animals were subjected to intrarenal injection of 100 μ l normal saline and PRP, respectively. 3 days later, the rats scarified under the deep anaesthesia and their kidneys were removed, prepared histologically and stained. The stereological methods were used for estimating the number of epithelial cells in convoluted tubules. Data analysis was done using SPSS 26. Differences between groups were compared with one-way analysis of variance and Duncan’ s multiple range test. p<0. 05 was considered as significant. Results: PRP increased the number of epithelial cells in the convoluted tubules in Gentamicintreated animals (p<0. 05). Conclusion: It seems that PRP can induce Proliferation of epithelial cells of convoluted tubules in Gentamicin-treated rat model.

Cites

No record.

References

No record.

Cite

APA: Copy

MAFI, A., MOGHADAM, A., & MOGHADAM, N.. (2020). Stereological Evaluation of Cell Proliferation following Intrarenal Injection of Platelet-rich Plasma in Gentamicin-treated Rats. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 19(4 ), 418-429. SID. https://sid.ir/paper/388695/en

Vancouver: Copy

MAFI A., MOGHADAM A., MOGHADAM N.. Stereological Evaluation of Cell Proliferation following Intrarenal Injection of Platelet-rich Plasma in Gentamicin-treated Rats. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2020;19(4 ):418-429. Available from: https://sid.ir/paper/388695/en

IEEE: Copy

A. MAFI, A. MOGHADAM, and N. MOGHADAM, “Stereological Evaluation of Cell Proliferation following Intrarenal Injection of Platelet-rich Plasma in Gentamicin-treated Rats,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 19, no. 4 , pp. 418–429, 2020, [Online]. Available: https://sid.ir/paper/388695/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops