THE ROLE OF GAD65 AUTOANTIBODY IN DIABETES MELLITUS AND THEIR FIRST-DEGREE RELATIVES AND COMPARISON WITH HEALTHY PERSONS

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KEIHANI M.; NAKHJAVANI M.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2001 | Volume:59 | Issue:1 Page(s): 21-25

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Title

THE ROLE OF GAD65 AUTOANTIBODY IN DIABETES MELLITUS AND THEIR FIRST-DEGREE RELATIVES AND COMPARISON WITH HEALTHY PERSONS

Author(s)

KEIHANI M. | NAKHJAVANI M. | Issue Writer Certificate

Keywords

DIABETES TYPE 1Q4

GLUTAMIC ACID DECARBOXYLASE AUTOANTIBODIES (GAD65-AB)Q4

CLOSE RELATIVESQ4

SCREENING TESTQ4

Abstract

The diabetes is an autoimmune disease, in which the role of autoantibodies is of a specific importance. The appearance of these autoantibodies can be the first symptom in the serum of type I diabetic patients, which may appear ten years before onest of the disease. The most important autoantibodies include Glutamic acid decarboxylase autoantibodies (GAD65-Ab). his can be used as a good tool for prediction in SCREENING TESTs in type I diabetic patients.In the present study with prosedure RIA, we investigated the level of GAD65-Ab in patients with diabetes type I and their CLOSE RELATIVES, and compared them with healthy persons.From the type 1 diabetic patients who have been suffering from the disease for periods of one week to twenty years, 63.3% of them had positive Anti-GAD658. This ratio was 8% in their CLOSE RELATIVES, and 0% in healthy persons. The difference in Anti-GAD65 between the healthy persons and CLOSE RELATIVES of patients was significant.This test may be employed in diabetes type I, as a SCREENING TEST, and confirms the results of studies which have been conducted so far outside this country.

Cites

میزان اتو آنتی بادی ضد گلوتامیک اسید در بیماران دیابتی نوع دو و وابستگان درجه اول آنها

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APA: Copy

KEIHANI, M., & NAKHJAVANI, M.. (2001). THE ROLE OF GAD65 AUTOANTIBODY IN DIABETES MELLITUS AND THEIR FIRST-DEGREE RELATIVES AND COMPARISON WITH HEALTHY PERSONS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 59(1), 21-25. SID. https://sid.ir/paper/38930/en

Vancouver: Copy

KEIHANI M., NAKHJAVANI M.. THE ROLE OF GAD65 AUTOANTIBODY IN DIABETES MELLITUS AND THEIR FIRST-DEGREE RELATIVES AND COMPARISON WITH HEALTHY PERSONS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2001;59(1):21-25. Available from: https://sid.ir/paper/38930/en

IEEE: Copy

M. KEIHANI, and M. NAKHJAVANI, “THE ROLE OF GAD65 AUTOANTIBODY IN DIABETES MELLITUS AND THEIR FIRST-DEGREE RELATIVES AND COMPARISON WITH HEALTHY PERSONS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 59, no. 1, pp. 21–25, 2001, [Online]. Available: https://sid.ir/paper/38930/en

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