THE RELATIONSHIP BETWEEN TOTAL LYMPHOCYTE COUNT AND CD4 COUNT IN PATIENTS INFECTED WITH HIV

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JAFARI SIROUS; RASOULINEZHAD MEHRNAZ; EMADI KOUCHAK H.; MOKARAMI F.

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Journal: Tehran University Medical Journal Year:2009 | Volume:67 | Issue:7 Page(s): 477-482

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Title

THE RELATIONSHIP BETWEEN TOTAL LYMPHOCYTE COUNT AND CD4 COUNT IN PATIENTS INFECTED WITH HIV

Author(s)

JAFARI SIROUS | RASOULINEZHAD MEHRNAZ | EMADI KOUCHAK H. | MOKARAMI F. | Issue Writer Certificate

Keywords

HUMAN IMMUNODEFICIENCY VIRUS (HIV)Q3

CD4 COUNTQ3

TOTAL LYMPHOCYTE COUNTQ3

Abstract

Background: CD4 T-Lymphocyte counts have proven to be a standard laboratory marker of disease progression and severity of immunodeficiency in adults infected with HIV is used to initiate and monitor highly active antiretroviral therapy; however, its application may not be feasible for its expensive equipments and reagent in resourcelimited setting. There is a need to have another marker of immunodeficiency that is less resource-demanding. In April 2002, the World Health Organization (WHO) recommended that, when CD4 cell count is not available, a TLC of 1200cell/mm3 or less in individuals with stage 2 or 3 of the disease may be used as an indication to initiate ART.Methods: The aim of this study was to determine the relationship between TOTAL LYMPHOCYTE COUNT and CD4 COUNT in HIV-infected adults. This was a retrospective cross-sectional study. Subject characteristics were patients who had positive serologic HIV test results, confirmed via western blot. Analysis unit was the results of CBC and CD4 measurements on the same blood sample each time. Data of 100 patients were collected. In this study, TLC accounts for the main predictor of CD4 COUNT. The amounts of TLC which can predict CD4 less than 200cell/mm3 were considered eligible.Results: Our data revealed high sensitivity and specificity of TLC as a surrogate measure of CD4 COUNT. In this study, TLC cutoff of 1300cell/mm3 indicated the optimal combined sensitivity and specificity altogether. Conclusion: TOTAL LYMPHOCYTE COUNT and its changes can be used as alternative to CD4 COUNT and its changes in the management of HIV-infected individuals.

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APA: Copy

JAFARI, SIROUS, RASOULINEZHAD, MEHRNAZ, EMADI KOUCHAK, H., & MOKARAMI, F.. (2009). THE RELATIONSHIP BETWEEN TOTAL LYMPHOCYTE COUNT AND CD4 COUNT IN PATIENTS INFECTED WITH HIV. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 67(7), 477-482. SID. https://sid.ir/paper/38993/en

Vancouver: Copy

JAFARI SIROUS, RASOULINEZHAD MEHRNAZ, EMADI KOUCHAK H., MOKARAMI F.. THE RELATIONSHIP BETWEEN TOTAL LYMPHOCYTE COUNT AND CD4 COUNT IN PATIENTS INFECTED WITH HIV. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;67(7):477-482. Available from: https://sid.ir/paper/38993/en

IEEE: Copy

SIROUS JAFARI, MEHRNAZ RASOULINEZHAD, H. EMADI KOUCHAK, and F. MOKARAMI, “THE RELATIONSHIP BETWEEN TOTAL LYMPHOCYTE COUNT AND CD4 COUNT IN PATIENTS INFECTED WITH HIV,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 67, no. 7, pp. 477–482, 2009, [Online]. Available: https://sid.ir/paper/38993/en

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