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Information Journal Paper

Title

Characterization of Antibiotic Resistance Profile and Detection of pap and blaCTX-Genes in Escherichia coli Isolates

Pages

  448-467

Abstract

 Aims: Escherichia coli is one of the most important causes of hospital-acquired and community-acquired infections in humans and can easily gain resistance to antibiotics consumed by humans and animals. The main objectives of this study were to assess antibiotic resistance outlines and detection of antibiotic resistance and virulence genes, including the blaCTX-M and pap among the E. coli isolates recovered from the urine of patients referred to Shaheed Madani Hospital (Bejestan, Northeast of Iran). Methods & Materials: This cross-sectional study was conducted from April 2016 to March 2018. A total of 100 non-duplicate isolates of E. coli were recovered from the urine of patients referred to Shaheed Madani Hospital (Bejestan, Northeast of Iran). Antimicrobial susceptibility test and extended-spectrumbeta-Lactamases (ESBLs) production were performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines. The polymerase chain reaction was carried out for the detection and distribution of the pap virulence gene and blaCTX-M antibiotic resistance gene. Findings: About 100 E. coli isolates were recovered from the urine sample of patients (21 male, and 79 female). Carbapenems were the most effective antibiotic against isolates. Four strains (4%) were resistant to colistin. Twenty-seven strains (27%) were ESBL-positive. Carbapenems were the most effective antibiotic against ESBL-positive strains. Also, 82% and 89% of isolates were blaCTX-M and pap gene positive, respectively. Conclusion: This study has shown that ESBL-positive strains with a high level of drug resistance and virulence factors are a potential risk for hospital wards. Colistin resistant isolates found in our study are quite alarming.

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    APA: Copy

    Mosadegh, Ahmad, ASTANI, AKRAM, NAGHIZADEH, HAMID, & MARDANEH, JALAL. (2020). Characterization of Antibiotic Resistance Profile and Detection of pap and blaCTX-Genes in Escherichia coli Isolates. OFOGH-E-DANESH, 26(4 ), 448-467. SID. https://sid.ir/paper/389940/en

    Vancouver: Copy

    Mosadegh Ahmad, ASTANI AKRAM, NAGHIZADEH HAMID, MARDANEH JALAL. Characterization of Antibiotic Resistance Profile and Detection of pap and blaCTX-Genes in Escherichia coli Isolates. OFOGH-E-DANESH[Internet]. 2020;26(4 ):448-467. Available from: https://sid.ir/paper/389940/en

    IEEE: Copy

    Ahmad Mosadegh, AKRAM ASTANI, HAMID NAGHIZADEH, and JALAL MARDANEH, “Characterization of Antibiotic Resistance Profile and Detection of pap and blaCTX-Genes in Escherichia coli Isolates,” OFOGH-E-DANESH, vol. 26, no. 4 , pp. 448–467, 2020, [Online]. Available: https://sid.ir/paper/389940/en

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