ULTRASTRUCTURAL HISTOPATHOLOGICAL STUDY OF IRRADIATED RAT CERVICAL SPINAL CORD

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MINAEI ZANGI M.B.; MAHDAVI S.R.; SHIRAZI A.; MORADIAN K.; NIKOUFAR A.R.; AZIZI E.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:63 | Issue:8 Page(s): 607-614

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Title

ULTRASTRUCTURAL HISTOPATHOLOGICAL STUDY OF IRRADIATED RAT CERVICAL SPINAL CORD

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Keywords

SPINAL CORD IRRADIATIONQ4

RADIATION MYELOPATHYQ4

VASCULARITIESQ4

DEMYELINATIONQ4

HISTOPATHOLOGYQ4

Abstract

Background: Involvement of vascular changes in developing RADIATION MYELOPATHY has already been reported. Therefore, we decided to detennine the irradiation responses of histopathological changes in irradiated rat cervical spinal cord and its contribution to RADIATION MYELOPATHY.Materials and Methods: Wistar rats (5 per group) were irradiated with doses of 0,2,4, 6, 15,25,30 and 35 Gy of X-ray in a specially designed jig through 3 cm irradiation portals. Samples of spinal cord were prepared for histopathological studies at 24 hours, 2, 13 weeks and single group of 35 Gy at 17 post irradiation. Tissue sections of spinal cord were studied by light and electron microscopy for structural and ultra-structural studies, respectively.Results: Histopathological findings showed marked graded gliosis, vascular density reduction, DEMYELINATION and endothelial changes in our short-tenn study. Conclusions: Therefore, our results can further emphasize on the possible important role of vascular changes in toxic effects of irradiation. Long-tenn studies, up to 39 weeks post irradiation, are also undergoing to detennine late effects of irradiation including myelopathy.

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APA: Copy

MINAEI ZANGI, M.B., MAHDAVI, S.R., SHIRAZI, A., MORADIAN, K., NIKOUFAR, A.R., & AZIZI, E.. (2005). ULTRASTRUCTURAL HISTOPATHOLOGICAL STUDY OF IRRADIATED RAT CERVICAL SPINAL CORD. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 63(8), 607-614. SID. https://sid.ir/paper/39004/en

Vancouver: Copy

MINAEI ZANGI M.B., MAHDAVI S.R., SHIRAZI A., MORADIAN K., NIKOUFAR A.R., AZIZI E.. ULTRASTRUCTURAL HISTOPATHOLOGICAL STUDY OF IRRADIATED RAT CERVICAL SPINAL CORD. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;63(8):607-614. Available from: https://sid.ir/paper/39004/en

IEEE: Copy

M.B. MINAEI ZANGI, S.R. MAHDAVI, A. SHIRAZI, K. MORADIAN, A.R. NIKOUFAR, and E. AZIZI, “ULTRASTRUCTURAL HISTOPATHOLOGICAL STUDY OF IRRADIATED RAT CERVICAL SPINAL CORD,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 63, no. 8, pp. 607–614, 2005, [Online]. Available: https://sid.ir/paper/39004/en

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