Association of rs4648551 polymorphism in p73 gene in Iranian woman with idiopathic recurrent pregnancy loss

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Tabasi Somayeh; HOSEINI SEYED MOSTAFA

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2020 | Volume:23 | Issue:7 Page(s): 69-77

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Title

Association of rs4648551 polymorphism in p73 gene in Iranian woman with idiopathic recurrent pregnancy loss

Author(s)

Tabasi Somayeh | HOSEINI SEYED MOSTAFA | Issue Writer Certificate

Keywords

PolymorphismQ1

P73 geneQ1

Recurrent Pregnancy Loss (RPL)Q1

Single nucleotide polymorphism (SNP)Q1

Abstract

Introduction: Recurrent pregnancy loss (RPL) is defined as the repeated occurrence of 2 or more miscarriages before 20th week of gestation. RPL is a multifactorial disorder and genetic defects are considered as one of the major risk factors for recurrent miscarriage. Regarding to the effective role of P73 gene in the process of primary blastocyst division and protection of germ cells, it seems that rs4648551 Polymorphism in this P73 gene be associated with the occurrence of spontaneous abortion symptoms. This study was performed with aim to evaluate the frequency of this Polymorphism between two groups of Iranian women with idiopathic recurrent miscarriage and healthy women. Methods: This descriptive case-control study was performed in 2015-2016 on 90 patients with history of 2 consecutive idiopathic recurrent spontaneous miscarriages compared to 110 healthy women who had at least two successful pregnancies as controls. DNA was extracted by RGDE procedure and genotyping was performed by Tetra ARMS technique. Data were analyzed by SPSS software (version 22) and Chi-square test. p < 0. 05 was considered statistically significant. Results: In SNP rs4648551(A

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APA: Copy

Tabasi, Somayeh, & HOSEINI, SEYED MOSTAFA. (2020). Association of rs4648551 polymorphism in p73 gene in Iranian woman with idiopathic recurrent pregnancy loss. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 23(7 ), 69-77. SID. https://sid.ir/paper/390122/en

Vancouver: Copy

Tabasi Somayeh, HOSEINI SEYED MOSTAFA. Association of rs4648551 polymorphism in p73 gene in Iranian woman with idiopathic recurrent pregnancy loss. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2020;23(7 ):69-77. Available from: https://sid.ir/paper/390122/en

IEEE: Copy

Somayeh Tabasi, and SEYED MOSTAFA HOSEINI, “Association of rs4648551 polymorphism in p73 gene in Iranian woman with idiopathic recurrent pregnancy loss,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 23, no. 7 , pp. 69–77, 2020, [Online]. Available: https://sid.ir/paper/390122/en

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