Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat

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Safakhah Hossein Ali; Jarrahi Morteza; RASHIDY POUR ALI; BANDEGI AHMAD REZA; Khazani Fariba

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Journal: Koomesh Year:2021 | Volume:23 | Issue:1 (81) Page(s): 95-104

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Title

Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat

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Keywords

NeuralgiaQ1

ExerciseQ2

ProgesteroneQ2

Abstract

Introduction: Neuropathic pain has no definitive treatment and the socio-economic status and personality of patient is severely affected. Since the Exercise and/or Progesterone effect on Chronic Constriction injury (CCI) neuropathic pain has been studied and each individually have been able to improve neuropathic pain and as a part of its etiology is related to TNF-α production, we tried to test these factors on TNF-α production and electrophysiologic responses of sciatic nerve in neuropathic pain model in rat. Materials and Methods: 50 male Wistar rats were used in 5 groups. Experimental groups were including: 1-Sham, 2-CCI + Vehicle (VEH), 3-CCI + VEH + Exercise, 4-CCI + Progestrone and 5-CCI + Progestrtone + Exercise. The sciatic nerve CCI model of rat was used to induce chronic neuropathic pain in the respective groups. Some groups of animals treated by Progesterone injections (6 mg/kg) or its vehicle from day 1 to day 12 after surgery. The Exercise was started two weeks before surgery and again, one-week after that and lasted to day 12. Electrophysiological tests and blood sampling were done on day 13. Results: The results showed that co administration of Progesterone for 12 days and moderate intensity Exercise for 3 weeks before complete neuropathic pain evolution could prevent significantly TNF-α production and electrophysiologic (Tibial and sural nerve conduction velocity) abnormality compared to the CCI group as well as compared to the Exercise or Progesterone group alone. Conclusion: The findings of this study showed that co-administration of Progesterone and forced Exercise before neuropathy development may prevent TNF-α production and neuropathic disease. Also, the results showed that the effects of co-administration of Progesterone and forced Exercise in preventing electrophysiologic abnormality may be additive.

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APA: Copy

Safakhah, Hossein Ali, Jarrahi, Morteza, RASHIDY POUR, ALI, BANDEGI, AHMAD REZA, & Khazani, Fariba. (2021). Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat. KOOMESH, 23(1 (81) ), 95-104. SID. https://sid.ir/paper/390237/en

Vancouver: Copy

Safakhah Hossein Ali, Jarrahi Morteza, RASHIDY POUR ALI, BANDEGI AHMAD REZA, Khazani Fariba. Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat. KOOMESH[Internet]. 2021;23(1 (81) ):95-104. Available from: https://sid.ir/paper/390237/en

IEEE: Copy

Hossein Ali Safakhah, Morteza Jarrahi, ALI RASHIDY POUR, AHMAD REZA BANDEGI, and Fariba Khazani, “Combined effect of chronic progesterone administration with compulsive exercise on prevention of TNF-α production and abnormal electrophysiological responses of sciatic nerve in Chronic Constriction injury pain model in rat,” KOOMESH, vol. 23, no. 1 (81) , pp. 95–104, 2021, [Online]. Available: https://sid.ir/paper/390237/en

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