STUDYING ANGIOGENESIS IN AUTOCHTHONOUS XENOGRAFT MODELS OF GLIOBLASTOMA MULTIFORME BY MVD-CD34 TECHNIQUE IN IRANIAN PATIENTS

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AMANPOUR SAEID; MUHAMMADNEJAD SAMAD; MUHAMMADNEJAD AHAD; MAZAHERI ZOHREH; KAZEM HAGHIGHI MARYAM; OGHABIAN MOHAMMADALI; KHOSHNEVISAN ALIREZA

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2011 | Volume:69 | Issue:3 Page(s): 141-144

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Title

STUDYING ANGIOGENESIS IN AUTOCHTHONOUS XENOGRAFT MODELS OF GLIOBLASTOMA MULTIFORME BY MVD-CD34 TECHNIQUE IN IRANIAN PATIENTS

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Keywords

ANGIOGENESISQ2

CD34Q2

GLIOBLASTOMA MULTIFORMQ2

MICROVESSEL DENSITYQ2

XENOGRAFT MODELQ2

Abstract

Background: Despite advances in cancer diagnosis and treatment, survival rate of patients suffering fromglioblastoma multiform (GBM) has not been significantly improved. Therefore, novel therapeutic adjuncts to routine therapies have been suggested over time. Inhibition of ANGIOGENESIS by antiangiogenic drugs is one of the new approaches to inhibit the growth of malignant cells. MICROVESSEL DENSITY (MVD) assay is a technique performed by counting immunohistochemically-stained blood vessels. Nowadays, athymic nude mice are widely used for the establishment of xenograft tumor models in cancer research. The aim of this study was to evaluate the MVDof autochthonous XENOGRAFT MODELs of GBM isolated from Iranian patients for use in pharmaceutical research on antiangiogenic drugs.Methods: Fresh tumor samples of GBM were obtained from three patients in Cancer Institute of Tehran University of Medical Sciences in Fall of 2010 and Winter of 2011. After preliminary processing, minced tumor samples were implanted heterotopically on flanks of athymic nude mice. Two months later, the animals were sacrificed and the xenograft tumor samples were sent to the pathology laboratory. After establishing the proof of the xenograft tumor type, MVD-CD34, an endothelial cell marker, was assessed by counting hot spot areas in 22 samples.Results: The mean number of microvessels in these xenograft tumor models was 30±2.1.Conclusion: These autochthonous XENOGRAFT MODELs of GBM can be used in preclinical settings for research on antiangiogenic drugs regarding a pharmacogenomics-based treatment regimen for the Iranian population. Moreover, such models can be used in future studies for determining the sensitivity or resistance to antiangiogenic drugs in individualized cancer therapy.

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APA: Copy

AMANPOUR, SAEID, MUHAMMADNEJAD, SAMAD, MUHAMMADNEJAD, AHAD, MAZAHERI, ZOHREH, KAZEM HAGHIGHI, MARYAM, OGHABIAN, MOHAMMADALI, & KHOSHNEVISAN, ALIREZA. (2011). STUDYING ANGIOGENESIS IN AUTOCHTHONOUS XENOGRAFT MODELS OF GLIOBLASTOMA MULTIFORME BY MVD-CD34 TECHNIQUE IN IRANIAN PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(3), 141-144. SID. https://sid.ir/paper/39055/en

Vancouver: Copy

AMANPOUR SAEID, MUHAMMADNEJAD SAMAD, MUHAMMADNEJAD AHAD, MAZAHERI ZOHREH, KAZEM HAGHIGHI MARYAM, OGHABIAN MOHAMMADALI, KHOSHNEVISAN ALIREZA. STUDYING ANGIOGENESIS IN AUTOCHTHONOUS XENOGRAFT MODELS OF GLIOBLASTOMA MULTIFORME BY MVD-CD34 TECHNIQUE IN IRANIAN PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(3):141-144. Available from: https://sid.ir/paper/39055/en

IEEE: Copy

SAEID AMANPOUR, SAMAD MUHAMMADNEJAD, AHAD MUHAMMADNEJAD, ZOHREH MAZAHERI, MARYAM KAZEM HAGHIGHI, MOHAMMADALI OGHABIAN, and ALIREZA KHOSHNEVISAN, “STUDYING ANGIOGENESIS IN AUTOCHTHONOUS XENOGRAFT MODELS OF GLIOBLASTOMA MULTIFORME BY MVD-CD34 TECHNIQUE IN IRANIAN PATIENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 3, pp. 141–144, 2011, [Online]. Available: https://sid.ir/paper/39055/en

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