THE EFFECTS OF METFORMIN ON OVUM IMPLANTATION AND PREGNANCY OUTCOME IN RATS WITH INDUCED PCOS

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MESBAH FAKHRODDIN; BAHRI AYESHEH; GHASEMI ELHAM; TALAEI KHOZANI TAHEREH; MIRKHANI HOSEEIN; PARSANEZHAD MOHAMMAD EBRAHIM

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2011 | Volume:69 | Issue:3 Page(s): 191-196

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Title

THE EFFECTS OF METFORMIN ON OVUM IMPLANTATION AND PREGNANCY OUTCOME IN RATS WITH INDUCED PCOS

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Keywords

METFORMINQ2

PCOSQ2

PREGNANCYQ2

RATQ3

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. METFORMIN which is effectively used for the treatment of anovulatory PCOS improves PREGNANCY RATe and endometrial receptivity and reduces the risk of miscarriage. The aim of this study was to evaluate the effects of METFORMIN on the endometrium, the number of fetuses and hormonal levels of PCOS RATs.Methods: Forty female adult Sprague-Dawley RATs were assigned randomly into four equal groups. Group I: control RATs, group II: RATs receiving METFORMIN (150 mg/kg/day), group III: Estradiol Valerate-induced PCOS RATs (4 mg/rat) and group IV: induced PCOS RATs receiving METFORMIN. Body weight and serum levels of glucose, LH, FSH, testosterone, progesterone and estradiol were measured. Following mating, each group was divided into two subgroups and the RATs were sacrificed on the 5th and 15th day of gestation to evaluate endometrial reaction to implantation and fetus count, respectively.Results: Hormone assay showed a significant increase in testosterone, estradiol, LH, FSH and blood glucose levels in group III compared to the controls (P£0.01) and a significant decrease in blood glucose in group IV versus group III (P£0.01). Progesterone concentration had no significant differences between groups III and the controls. Weight was higher in group III than group I but it had no decrease after METFORMIN administration. No significant differences were detected regarding implantation RATe and number of fetuses in all RATs.Conclusion: METFORMIN has significant effects on PREGNANCY RATe and the hormonal and blood glucose levels of Estradiol Valerate-induced PCOS RATs.

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APA: Copy

MESBAH, FAKHRODDIN, BAHRI, AYESHEH, GHASEMI, ELHAM, TALAEI KHOZANI, TAHEREH, MIRKHANI, HOSEEIN, & PARSANEZHAD, MOHAMMAD EBRAHIM. (2011). THE EFFECTS OF METFORMIN ON OVUM IMPLANTATION AND PREGNANCY OUTCOME IN RATS WITH INDUCED PCOS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(3), 191-196. SID. https://sid.ir/paper/39056/en

Vancouver: Copy

MESBAH FAKHRODDIN, BAHRI AYESHEH, GHASEMI ELHAM, TALAEI KHOZANI TAHEREH, MIRKHANI HOSEEIN, PARSANEZHAD MOHAMMAD EBRAHIM. THE EFFECTS OF METFORMIN ON OVUM IMPLANTATION AND PREGNANCY OUTCOME IN RATS WITH INDUCED PCOS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(3):191-196. Available from: https://sid.ir/paper/39056/en

IEEE: Copy

FAKHRODDIN MESBAH, AYESHEH BAHRI, ELHAM GHASEMI, TAHEREH TALAEI KHOZANI, HOSEEIN MIRKHANI, and MOHAMMAD EBRAHIM PARSANEZHAD, “THE EFFECTS OF METFORMIN ON OVUM IMPLANTATION AND PREGNANCY OUTCOME IN RATS WITH INDUCED PCOS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 3, pp. 191–196, 2011, [Online]. Available: https://sid.ir/paper/39056/en

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