The effect of moderate intensity endurance training on some fatty liver and metabolic indices in diabetic women with non-alcoholic fatty liver

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astinchap afsaneh; Monazzami Amirabbas; RAHIMI ZOHREH; RAHIMI MEHRALI

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Journal: IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY Year:2020 | Volume:4 | Issue:1 (13) Page(s): 49-58

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Title

The effect of moderate intensity endurance training on some fatty liver and metabolic indices in diabetic women with non-alcoholic fatty liver

Author(s)

astinchap afsaneh | Monazzami Amirabbas | RAHIMI ZOHREH | RAHIMI MEHRALI | Issue Writer Certificate

Keywords

βKlotho

Endurance training

Type 2 diabetes

Fibroblast growth factor 21

Insulin resistance

Abstract

Background and aims: Research on the effects of Endurance training on Fibroblast growth factor 21 (FGF21) and β Klotho protein expression in patient with nonalcoholic fatty liver disease (NAFLD) is limited. We aimed to determine effects of eight weeks Endurance training with moderate intensity on FGF21 and β Klotho protein expression in diabetic women with NAFLD. Methods: Thirty diabetic women (age 53 ± 7, height 158 ± 4, weight 75 ± 9) with NAFLD participated in this study Subjects were randomly divided into two groups of control (n = 15) and exercise (n = 15). The training was performed by running in each session for 30-45 min with 60-70% of the heart rate reserve and three sessions per week for eight weeks. Control group did not perform any exercise program. Rockport walking test and ELISA technique were used to measure VO2max and β Klotho and FGF21 protein expression, respectively. Two-way ANOVA test with repeated measures and p < 0. 05 was used to determine the significant differences. Results: Except for β Klotho serum level, none of the other variables of the control group showed significant difference in pre and post training. However, in the training group, weight, fat percent, body mass index, Waist to hip ratio, insulin, glucose, β Klotho and FGF21 levels were significantly changed after training (p < 0. 05). A significant difference was observed between control and training groups in β Klotho and FGF21 levels (p < 0. 05). Conclusion: Endurance training could improve imbalance of FGF21 and β Klotho protein expression in women with Type 2 diabetes and NAFLD.

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APA: Copy

astinchap, afsaneh, Monazzami, Amirabbas, RAHIMI, ZOHREH, & RAHIMI, MEHRALI. (2020). The effect of moderate intensity endurance training on some fatty liver and metabolic indices in diabetic women with non-alcoholic fatty liver. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 4(1 (13) ), 49-58. SID. https://sid.ir/paper/390661/en

Vancouver: Copy

astinchap afsaneh, Monazzami Amirabbas, RAHIMI ZOHREH, RAHIMI MEHRALI. The effect of moderate intensity endurance training on some fatty liver and metabolic indices in diabetic women with non-alcoholic fatty liver. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2020;4(1 (13) ):49-58. Available from: https://sid.ir/paper/390661/en

IEEE: Copy

afsaneh astinchap, Amirabbas Monazzami, ZOHREH RAHIMI, and MEHRALI RAHIMI, “The effect of moderate intensity endurance training on some fatty liver and metabolic indices in diabetic women with non-alcoholic fatty liver,” IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 4, no. 1 (13) , pp. 49–58, 2020, [Online]. Available: https://sid.ir/paper/390661/en

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