Comparison of Intravenous Paracetamol versus Intravenous Ibuprofen in the Closure of Patent Ductus Arteriosus (PDA) in Preterm Infants

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SABZEHEI MOHAMMAD KAZEM; TANASAN ASADOLAH; MOHAMMADI YONES; Taheri Talesh Soroush; ZEINALI MARYAM

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Journal: PAJOUHAN SCIENTIFIC JOURNAL Year:2020 | Volume:19 | Issue:1 Page(s): 53-61

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Title

Comparison of Intravenous Paracetamol versus Intravenous Ibuprofen in the Closure of Patent Ductus Arteriosus (PDA) in Preterm Infants

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Keywords

IbuprofenQ1

AcetaminophenQ1

PDAQ1

Preterm InfantQ1

Abstract

Background and Objective: The Patent Ductus Arteriosus (PDA) occurs in 50% of infants under 1000 g and 30% of infants less than 1500 g. Treatment failure can exacerbate respiratory distress and its complications. Acetaminophen is a new drug with fewer side effects. The present study was designed and performed to evaluate the effect of this drug and intravenous Ibuprofen on the treatment of Patent Ductus Arteriosus. Materials and Methods: In this case-control study, 50 Preterm Infants who were less or equal to 14 days of age and diagnosis of PDA by echocardiographic were included and randomly divided into two groups. The first group was treated with intravenous Ibuprofen and the second group was treated with intravenous Acetaminophen for three days. At the end, the necessary information, including echocardiographic findings were analyzed using SPSS software version 16. Results: The findings of the present study showed that both Ibuprofen and Acetaminophen had equal effect in the closing of PDA in Preterm Infants. There was no significant difference in the duration of hospitalisation between two groups (P = 0. 259). Possible side effects include intraventricular hemorrhage, thrombocytopenia, serum creatinine greater than 1. 5 mg / dl, decreased urinary volume, necrotizing enterocolitis, positive blood culture and bronchopulmonary dysplasia were not significantly different between the two groups. The only significant complication was gastrointestinal bleeding, which was almost equally prevalent in both groups. Conclusion: Acetaminophen such as Ibuprofen is effective as the main treatment of patent ductus arteriosus (PDA) and it could be a safe alternative to Ibuprofen.

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APA: Copy

SABZEHEI, MOHAMMAD KAZEM, TANASAN, ASADOLAH, MOHAMMADI, YONES, Taheri Talesh, Soroush, & ZEINALI, MARYAM. (2020). Comparison of Intravenous Paracetamol versus Intravenous Ibuprofen in the Closure of Patent Ductus Arteriosus (PDA) in Preterm Infants. PAJOUHAN SCIENTIFIC JOURNAL, 19(1 ), 53-61. SID. https://sid.ir/paper/391725/en

Vancouver: Copy

SABZEHEI MOHAMMAD KAZEM, TANASAN ASADOLAH, MOHAMMADI YONES, Taheri Talesh Soroush, ZEINALI MARYAM. Comparison of Intravenous Paracetamol versus Intravenous Ibuprofen in the Closure of Patent Ductus Arteriosus (PDA) in Preterm Infants. PAJOUHAN SCIENTIFIC JOURNAL[Internet]. 2020;19(1 ):53-61. Available from: https://sid.ir/paper/391725/en

IEEE: Copy

MOHAMMAD KAZEM SABZEHEI, ASADOLAH TANASAN, YONES MOHAMMADI, Soroush Taheri Talesh, and MARYAM ZEINALI, “Comparison of Intravenous Paracetamol versus Intravenous Ibuprofen in the Closure of Patent Ductus Arteriosus (PDA) in Preterm Infants,” PAJOUHAN SCIENTIFIC JOURNAL, vol. 19, no. 1 , pp. 53–61, 2020, [Online]. Available: https://sid.ir/paper/391725/en

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