Simulation of strand breaks induced in DNA molecule by radiation of proton and Secondary particles using Geant4 code

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Shamshiri Pezhman; Forozani Ghasem; Zabihi Azam

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Journal Paper

Paper Information

Journal: Journal of Radiation Safety and Measurement Year:2019 | Volume:8 | Issue:4 (supplement) Page(s): 147-154

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Information Journal Paper

Title

Simulation of strand breaks induced in DNA molecule by radiation of proton and Secondary particles using Geant4 code

Author(s)

Shamshiri Pezhman | Forozani Ghasem | Zabihi Azam | Issue Writer Certificate

Keywords

Radio therapyQ1

Single-strand breakQ1

Double-strand breakQ1

DNAQ2

Geant4Q1

Protein data bankQ1

Abstract

Radiotherapy using various beams is one of the methods for treating cancer, Hadrons used to treat cancers that are near critical organs. The most important part of the cell that is damage by ionizing radiation is DNA. In this study, damages induced in the genetic material of living cells (DNA) defined by the atomic model from the Protein data bank (PDB) have been studied by radiation of monoenergetic protons and its secondary particles using Geant4 code. The total SSB yield is independent of energy of incident particle. The total DSB yield is increase with increasing of incident particle LET. The ratio of total inelastic events to absorbed dose for primary protons as well as its secondary particles is independent of energy. The contribution of secondary particles in the formation of Single-strand breaks and Double-strand breaks have been calculated. The DSB yield generated by secondary particles is increase with decreasing the energy of the incident particle and the contribution of secondary particles to the generate of Double-strand break for energies less than 5 Mev is greater than their contribution to the creation of single-strande breaks. The ratio of Double-strand breaks to Single-strand breaks have been reduced by increasing the energy of the radiation particle.

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APA: Copy

Shamshiri, Pezhman, Forozani, Ghasem, & Zabihi, Azam. (2019). Simulation of strand breaks induced in DNA molecule by radiation of proton and Secondary particles using Geant4 code. IRANIAN JOURNAL OF RADIATION SAFETY AND MEASUREMENT, 8(4 (supplement) ), 147-154. SID. https://sid.ir/paper/392243/en

Vancouver: Copy

Shamshiri Pezhman, Forozani Ghasem, Zabihi Azam. Simulation of strand breaks induced in DNA molecule by radiation of proton and Secondary particles using Geant4 code. IRANIAN JOURNAL OF RADIATION SAFETY AND MEASUREMENT[Internet]. 2019;8(4 (supplement) ):147-154. Available from: https://sid.ir/paper/392243/en

IEEE: Copy

Pezhman Shamshiri, Ghasem Forozani, and Azam Zabihi, “Simulation of strand breaks induced in DNA molecule by radiation of proton and Secondary particles using Geant4 code,” IRANIAN JOURNAL OF RADIATION SAFETY AND MEASUREMENT, vol. 8, no. 4 (supplement) , pp. 147–154, 2019, [Online]. Available: https://sid.ir/paper/392243/en

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