THE PREPARATION OF ALBUMIN AS A BIOLOGICAL DRUG FROM HUMAN PLASMA BY FIBER FILTRATION

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MOUSAVI HOSSEINI KAMRAN; HEIDARI MAJID; YARI FATEMEH

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2011 | Volume:69 | Issue:5 Page(s): 283-288

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Title

THE PREPARATION OF ALBUMIN AS A BIOLOGICAL DRUG FROM HUMAN PLASMA BY FIBER FILTRATION

Author(s)

MOUSAVI HOSSEINI KAMRAN | HEIDARI MAJID | YARI FATEMEH | Issue Writer Certificate

Keywords

BLOOD PLASMAQ2

FRACTION V+VIQ3

FRACTIONATIONQ2

HUMAN ALBUMINQ2

PROTEINQ2

PURIFICATIONQ2

Abstract

Background: In recent years, consumption of whole-blood for the treatment of patients has decreased but use of biological plasma-derived medicines such as albumin, immunoglobulin and coagulation factors have increased instead. Paying attention to albumin molecular structure is important for its isolation from human plasma. Albumin is a single-chain PROTEIN consisting of about 585 amino acids and a molecular weight of 66500 Daltons. Albumin is a stable molecule and it is spherical in shape. There are different methods for HUMAN ALBUMIN preparation. Considering the large consumption of this biological drug in clinical settings, methods with fewer steps in production line are of big advantage in saving time and manufacturing more products.Methods: In this project, we prepared HUMAN ALBUMIN using hollow fiber cartridges in order to omit the rework on fraction V+VI. HUMAN ALBUMIN is usually produced by the application of cold ethanol method, where albumin is obtained from fraction V by doing a rework on fraction V+VI to separate fraction V.Results: In the current work, HUMAN ALBUMIN was prepared from fraction V+VI by the help of hollow fiber cartridges. With a concentration of 20%, the obtained albumin had 96.5% of monomer and 3.5% of polymer and polymer aggregate.Conclusion: Comparing the obtained HUMAN ALBUMIN with a number of commercial HUMAN ALBUMIN samples by the use of SDS-page, the results were satisfactory regarding the 3.5 percent polymer and aggregate rate for the prepared albumin

Cites

PATHOGEN INACTIVATION OF BLOOD DERIVED BIOLOGICAL MEDICINES: REVIEW ARTICLE

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APA: Copy

MOUSAVI HOSSEINI, KAMRAN, HEIDARI, MAJID, & YARI, FATEMEH. (2011). THE PREPARATION OF ALBUMIN AS A BIOLOGICAL DRUG FROM HUMAN PLASMA BY FIBER FILTRATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(5), 283-288. SID. https://sid.ir/paper/39240/en

Vancouver: Copy

MOUSAVI HOSSEINI KAMRAN, HEIDARI MAJID, YARI FATEMEH. THE PREPARATION OF ALBUMIN AS A BIOLOGICAL DRUG FROM HUMAN PLASMA BY FIBER FILTRATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(5):283-288. Available from: https://sid.ir/paper/39240/en

IEEE: Copy

KAMRAN MOUSAVI HOSSEINI, MAJID HEIDARI, and FATEMEH YARI, “THE PREPARATION OF ALBUMIN AS A BIOLOGICAL DRUG FROM HUMAN PLASMA BY FIBER FILTRATION,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 5, pp. 283–288, 2011, [Online]. Available: https://sid.ir/paper/39240/en

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