Synthesis and spectral characterization of a new binuclear organoplatinum(IV)-tin complex: investigation of cytotoxic effects on the MDA-MB-468 breast cancer and U-87MG glioblastoma cell lines

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Momeni Badri Zaman; Fathi Nastaran; Biglari Abbas; SHAHSAVARI ZAHRA

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Journal: JOURNAL OF APPLIED CHEMISTRY Year:2020 | Volume:15 | Issue:55 Page(s): 37-52

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Title

Synthesis and spectral characterization of a new binuclear organoplatinum(IV)-tin complex: investigation of cytotoxic effects on the MDA-MB-468 breast cancer and U-87MG glioblastoma cell lines

Author(s)

Momeni Badri Zaman | Fathi Nastaran | Biglari Abbas | SHAHSAVARI ZAHRA | Issue Writer Certificate

Keywords

OrganoplatinumQ1

OrganotinQ1

Oxidative additionQ1

SpectroscopyQ2

Cell linesQ1

CytotoxicityQ1

Abstract

The reaction of [PtMe2(4, 4'-Me2bpy)] (4, 4'-Me2bpy = 4, 4'-dimethyl-2, 2'-bipyridine) with [SnMe2(NCS)2] in a 1: 1 mole ratio led to the formation of [PtMe2(SnMe2NCS)(SCN)(4, 4'-Me2bpy)] via dissociation of the Sn-NCS bond. The product has been fully characterized by elemental analyses, UV-Vis, IR, (1H, 13C, 119Sn, 195Pt, HHCOSY, and HSQC) NMR Spectroscopy. On the basis of NMR data, the Pt(IV) product of the each contains almost exclusively the kinetic trans isomer corresponding to that of trans Oxidative addition of SnMe2(NCS)2. The IR spectrum of complex displays characteristic sharp absorptions resulting from the SCN and NCS groups of Pt-SCN and Sn-NCS units. In vitro anticancer activity of three analogues complexes trans-[PtMe2(SnMe2NCS)(SCN)(4, 4'-Me2bpy)], trans-[PtMe2(SnMe2Cl)(Cl)(4, 4'-Me2bpy)], and trans-[PtMe2(SnEt2Cl)(Cl)(4, 4'-Me2bpy)] were tested against human breast carcinoma (MDA-MB-468) and glioblastoma multiforme (U-87MG) Cell lines. The results show that trans-[PtMe2(SnEt2Cl)(Cl)(4, 4'-Me2bpy)] revealed higher cytotoxic effect towards both cancer Cell lines, which shows the significant role of the alkyl group.

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APA: Copy

Momeni, Badri Zaman, Fathi, Nastaran, Biglari, Abbas, & SHAHSAVARI, ZAHRA. (2020). Synthesis and spectral characterization of a new binuclear organoplatinum(IV)-tin complex: investigation of cytotoxic effects on the MDA-MB-468 breast cancer and U-87MG glioblastoma cell lines. JOURNAL OF APPLIED CHEMISTRY, 15(55 ), 37-52. SID. https://sid.ir/paper/392556/en

Vancouver: Copy

Momeni Badri Zaman, Fathi Nastaran, Biglari Abbas, SHAHSAVARI ZAHRA. Synthesis and spectral characterization of a new binuclear organoplatinum(IV)-tin complex: investigation of cytotoxic effects on the MDA-MB-468 breast cancer and U-87MG glioblastoma cell lines. JOURNAL OF APPLIED CHEMISTRY[Internet]. 2020;15(55 ):37-52. Available from: https://sid.ir/paper/392556/en

IEEE: Copy

Badri Zaman Momeni, Nastaran Fathi, Abbas Biglari, and ZAHRA SHAHSAVARI, “Synthesis and spectral characterization of a new binuclear organoplatinum(IV)-tin complex: investigation of cytotoxic effects on the MDA-MB-468 breast cancer and U-87MG glioblastoma cell lines,” JOURNAL OF APPLIED CHEMISTRY, vol. 15, no. 55 , pp. 37–52, 2020, [Online]. Available: https://sid.ir/paper/392556/en

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