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Information Journal Paper

Title

THE RELATIONSHIP BETWEEN CEREBROSPINAL FLUID C-REACTIVE PROTEIN AND NEONATAL MENINGITIS

Pages

  723-728

Abstract

 Background: MENINGITIS is one of the serious and dangerous infections in the infancy and childhood and rapid diagnosis of meningococcal disease is important, especially in infants. C-REACTIVE PROTEIN (CRP) is a protein found in blood and is an acute phase protein. CRP sensitive reactive that used for diagnosis of infection. This study conducted to assessment of the relationship between CEREBROSPINAL FLUID C-REACTIVE PROTEIN, and neonatal MENINGITIS, as well as diagnostic value of test.Methods: Forty nine hospitalized infant that suspected to MENINGITIS were enrolled in this analytic cross sectional research via non probable accessible sampling. 28 patients (52.7%) of all the patients were male and 21 patients (42.8%) were female. The average age of the patients was 22.6±11.88 days. Data from clinical examinations and laboratory tests entered in a questionnaire and all of samples divided in two bacterial (septic) and non-bactria (aseptic) MENINGITIS group. All data including CEREBROSPINAL FLUID CRP of newborns were statistically analyzed.Results: In total, the mean and standard deviation of age was 22.6±11.88 days. 57.2% of infants were male and 42.8% were female. In total, 40.82% of infants were diagnosed with septic MENINGITIS. There was no significant difference between septic and aseptic groups in terms of sex (P= 1.00) also in terms of age (P= 0.1). The mean and standard deviation of CRP level in septic MENINGITIS group was 0.95±0.68 mg/L and in aseptic group was 0.16±0.36 mg/L. The CRP level difference in septic MENINGITIS group compare with aseptic group was statistically significant (P<0.000). The finding showed that cut off point for CRP level as a diagnostic test was 0.17 mg/L, sensitivity was 95% and specificity was 86%.Conclusion: In the present study, newborns with septic MENINGITIS had higher CEREBROSPINAL FLUID CRP level than newborns with aseptic MENINGITIS, and CSF-CRP can be used in rapid diagnosis of septic and aseptic MENINGITIS. Although this result has been seen in many studies, but more research is needed.

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    APA: Copy

    KHOSRAVI, NASTARAN, KHALESI, NASRIN, NOURBAKHSH, SAMILEH, JAVADINIA, SHIMA, ASGARIAN, RAMIN, & TABATABAEI, AZARDOKHT. (2013). THE RELATIONSHIP BETWEEN CEREBROSPINAL FLUID C-REACTIVE PROTEIN AND NEONATAL MENINGITIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 71(11), 723-728. SID. https://sid.ir/paper/39262/en

    Vancouver: Copy

    KHOSRAVI NASTARAN, KHALESI NASRIN, NOURBAKHSH SAMILEH, JAVADINIA SHIMA, ASGARIAN RAMIN, TABATABAEI AZARDOKHT. THE RELATIONSHIP BETWEEN CEREBROSPINAL FLUID C-REACTIVE PROTEIN AND NEONATAL MENINGITIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2013;71(11):723-728. Available from: https://sid.ir/paper/39262/en

    IEEE: Copy

    NASTARAN KHOSRAVI, NASRIN KHALESI, SAMILEH NOURBAKHSH, SHIMA JAVADINIA, RAMIN ASGARIAN, and AZARDOKHT TABATABAEI, “THE RELATIONSHIP BETWEEN CEREBROSPINAL FLUID C-REACTIVE PROTEIN AND NEONATAL MENINGITIS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 71, no. 11, pp. 723–728, 2013, [Online]. Available: https://sid.ir/paper/39262/en

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