Comparison of efficacy and safety of levetiracetam, sodium valproate, and nortriptyline in the prevention of migraine headache

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RIASI HAMID REZA; AKBARI AYOB; AHANI ZAHRA; Musavi Mirzaee Sayed Mohammad

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Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2020 | Volume:27 | Issue:4 Page(s): 336-343

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Information Journal Paper

Title

Comparison of efficacy and safety of levetiracetam, sodium valproate, and nortriptyline in the prevention of migraine headache

Author(s)

RIASI HAMID REZA | AKBARI AYOB | AHANI ZAHRA | Musavi Mirzaee Sayed Mohammad | Issue Writer Certificate

Keywords

LevetiracetamQ1

MigraineQ2

NortriptylineQ3

Sodium ValproateQ2

Abstract

Background and Aims: Headache is the most common reason for referring to a physician. Therapeutic approaches of this condition include the treatment of the acute attacks and prevention of future attacks. In this regard, this study aimed to investigate the effect of three medications, namely Levetiracetam, Sodium Valproate, and Nortriptyline on the control of Migraine headaches in patients with Migraine referred to Birjand Neurology Clinic, Birjand, Iran. Materials and Methods: This study was conducted based on a quasi-experimental research method. According to the physician, 120 Migraine patients were divided into three groups of Levetiracetam (a daily dose of 250 mg), Sodium Valproate (500 mg), and Nortriptyline (25 mg) for four weeks. A questionnaire was used to collect the demographic characteristics of the patient. The data were analyzed using SPSS software (version 16) through the chi-square tets, paired t-test, and ANOVA. Results: The patients (n=120) were divided into three groups of 40 cases per group. The mean age of the patients was 33± 11 years, and the majority of the cases (53. 3%) were female. In total, 46. 7% of the cases had severe headache before taking these medications; however, none of them experienced severe headache after taking the medicine. It should be noted that 77. 5% of the patients experienced mild headache. The group taking Levetiracetam showed the greatest decrease in headache intensity (P=0. 01). Conclusion: According the results, Levetiracetam appears to be more effective than the other two medications, especially Sodium Valproate, in terms of the mitigation of different degrees of headache.

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References

COMPARISON OF THE EFFECT OF SODIUM VALPROATE AND LEVETIRACETAM ON THE PREVENTION OF MIGRAINE HEADACHES: A PROSPECTIVE STUDY

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APA: Copy

RIASI, HAMID REZA, AKBARI, AYOB, AHANI, ZAHRA, & Musavi Mirzaee, Sayed Mohammad. (2020). Comparison of efficacy and safety of levetiracetam, sodium valproate, and nortriptyline in the prevention of migraine headache. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 27(4 ), 336-343. SID. https://sid.ir/paper/392709/en

Vancouver: Copy

RIASI HAMID REZA, AKBARI AYOB, AHANI ZAHRA, Musavi Mirzaee Sayed Mohammad. Comparison of efficacy and safety of levetiracetam, sodium valproate, and nortriptyline in the prevention of migraine headache. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(4 ):336-343. Available from: https://sid.ir/paper/392709/en

IEEE: Copy

HAMID REZA RIASI, AYOB AKBARI, ZAHRA AHANI, and Sayed Mohammad Musavi Mirzaee, “Comparison of efficacy and safety of levetiracetam, sodium valproate, and nortriptyline in the prevention of migraine headache,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 4 , pp. 336–343, 2020, [Online]. Available: https://sid.ir/paper/392709/en

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