Protective role of vitamin-D on chronic stress inducedlearning and memory deficits in rats

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Choobdar Sara; VAFAEI ABBAS ALI; RASHIDY POUR ALI; SEDAGHAT KATAYOUN

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Journal Paper

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Journal: Koomesh Year:2019 | Volume:21 | Issue:4 (76) Page(s): 708-715

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Information Journal Paper

Title

Protective role of vitamin-D on chronic stress inducedlearning and memory deficits in rats

Author(s)

Choobdar Sara | VAFAEI ABBAS ALI | RASHIDY POUR ALI | SEDAGHAT KATAYOUN | Issue Writer Certificate

Keywords

Chronic Limiting StressQ2

HippocampusQ2

MemoryQ2

LearningQ1

Vitamin DQ2

CorticosteroneQ2

Morris Water MazeQ2

Passive-avoidance TestQ2

Abstract

Introduction: Long-term stress disturbs HPA axis and increases glucocorticoids release, which disturbs neural plasticity in the Hippocampus and may lead to Learning and Memory deficits. Noticeably, Vitamin D plays a protective role in the nervous system and has receptors in the Hippocampus. This behavioral study investigates the possible protective role of vitamin-D against the negative effects of chronic stress on Learning and Memory. Materials and Methods: All the Rats were randomly divided to two groups; stress and control groups (each had 3 subgroups). Stress-group animals were exposed to restraint stress for 28 days, 3 hours/day. During 28 days, Vitamin D (5 or 10 mg/kg), or vehicle was injected (IP) twice weekly to both groups. At day 29, blood sample collected for serum Corticosterone assay. Morris Water Maze (MWM) test was performed in the order of 4 days training, one-day probe testing and finally working Memory test. Passive avoidance test was performed after MWM. Results: Stress group revealed higher levels of serum Corticosterone (P <0. 0001) relative to controls. In MWM test, all groups learned the location of the platform during training. Latency in reaching the platform was reduced by the training days (P = 0. 0001) for all the groups. Probe test indicated that stress groups reached the platform sooner than the control groups. Higher dose of Vitamin D reduced this latency (P = 0. 0002). Conversely, in passive avoidance test, stress groups spent less time in the dark than the control group (P = 0. 0997). Vitamin D (10 μ g / kg) did not change the results. Conclusion: In this study, chronic restraint stress increased blood Corticosterone levels and changed the behavioral effects of long and short term spatial and conditional Memory. Treatment with Vitamin D improved spatial Learning.

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APA: Copy

Choobdar, Sara, VAFAEI, ABBAS ALI, RASHIDY POUR, ALI, & SEDAGHAT, KATAYOUN. (2019). Protective role of vitamin-D on chronic stress inducedlearning and memory deficits in rats. KOOMESH, 21(4 (76) ), 708-715. SID. https://sid.ir/paper/393352/en

Vancouver: Copy

Choobdar Sara, VAFAEI ABBAS ALI, RASHIDY POUR ALI, SEDAGHAT KATAYOUN. Protective role of vitamin-D on chronic stress inducedlearning and memory deficits in rats. KOOMESH[Internet]. 2019;21(4 (76) ):708-715. Available from: https://sid.ir/paper/393352/en

IEEE: Copy

Sara Choobdar, ABBAS ALI VAFAEI, ALI RASHIDY POUR, and KATAYOUN SEDAGHAT, “Protective role of vitamin-D on chronic stress inducedlearning and memory deficits in rats,” KOOMESH, vol. 21, no. 4 (76) , pp. 708–715, 2019, [Online]. Available: https://sid.ir/paper/393352/en

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