مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

1,075
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Study the Effect of Thymus Vulgaris In Inhibiting Acetylcholinesterase Enzyme in Order To Treat Alzheimer’ s Disease

Pages

  593-602

Abstract

 Introduction: Alzheimer’ s disease is the most common cause of dementia in the elderly and is characterized by loss of memory and other cognitive functions. The acetylcholinesterase enzyme (ACHE) with hydrolysis of the neurotransmitter acetylcholine in the cholinergic synapses of the brain plays a role in ending the neural message. One of the methods used to control the progression of Alzheimer’ s disease is the administration of cholinesterase inhibitors, especially plant-originated medicines. The aim of this study was to study bioinformatics and obtain the level of inhibitory effect of acetylcholinesterase enzyme by hydro-alcoholic extract of aerial organs of Thymus vulgaris. Materials and Methods: In order to investigate how the compounds are attached to the active site of the enzyme, first, Docking studies were conducted using AutoDock 4. 2 software, the hydro-alcoholic extract of Thymus vulgaris was measured at concentrations 2, 1, 0. 5, 0. 25 mg/ml in order to determine its inhibitory effect on acetylcholinesterase. Results: The compounds present in the extract were able to occupy the active site of the enzyme with a binding energy level of-4. 12 to-6. 58 kcal / mol. According to the laboratory results, concentrations of 2mg/ml were 46. 99% and IC50 = 2. 03 mg/ml. Conclusion: The results of in silico and in vitro studies indicate that the extract of this plant contains effective inhibitory compounds, and trying to use these compounds is a suitable topic for future research with the aim of acquiring pharmacologically inhibitors.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    NADERI, M., ASADZADEH, A., & HEIDARYAN NAEINI, F.. (2021). Study the Effect of Thymus Vulgaris In Inhibiting Acetylcholinesterase Enzyme in Order To Treat Alzheimer’ s Disease. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 27(5 ), 593-602. SID. https://sid.ir/paper/393582/en

    Vancouver: Copy

    NADERI M., ASADZADEH A., HEIDARYAN NAEINI F.. Study the Effect of Thymus Vulgaris In Inhibiting Acetylcholinesterase Enzyme in Order To Treat Alzheimer’ s Disease. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;27(5 ):593-602. Available from: https://sid.ir/paper/393582/en

    IEEE: Copy

    M. NADERI, A. ASADZADEH, and F. HEIDARYAN NAEINI, “Study the Effect of Thymus Vulgaris In Inhibiting Acetylcholinesterase Enzyme in Order To Treat Alzheimer’ s Disease,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 5 , pp. 593–602, 2021, [Online]. Available: https://sid.ir/paper/393582/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top