TERATOGENIC EFFECTS OF CAFFEINE AND CLOMIPRAMINE ON RAT FETUS

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TAKZARE NASRIN; NIKOUI VAHID; OSTADHADI SATTAR; NABAVI SEYYED MOHAMMAD ALI; BAKHTIARIAN AZAM

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Journal: Tehran University Medical Journal Year:2012 | Volume:70 | Issue:6 Page(s): 0-0

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Title

TERATOGENIC EFFECTS OF CAFFEINE AND CLOMIPRAMINE ON RAT FETUS

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Keywords

ANOMALIESQ3

CAFFEINEQ2

CLOMIPRAMINEQ3

FETUSQ2

RATQ2

TERATOGENQ3

TRICYCLIC ANTIDEPRESSANTSQ3

Abstract

Background: Obsessive-compulsive disorders and depression have a high prevalence during pregnancy; therefore, pregnant women may take CLOMIPRAMINE and also take other drugs or consume foods that contain CAFFEINE. As investigations about the TERATOGENic effects of CLOMIPRAMINE and its concurrent administration with CAFFEINE during organogenesis period are scarce, we aimed to study the TERATOGENicity of simultaneous administration of CLOMIPRAMINE and CAFFEINE in RAT FETUS.Methods: After dividing 42 pregnant RATs to several case and control groups, we injected different doses of CAFFEINE and CLOMIPRAMINE to the animals. All the injections were performed on the eighth until the 15th day of pregnancy. We removed the FETUSes on the 17th day of pregnancy and studied the morphological features and apparent ANOMALIES of the FETUSes macroscopically.Results: We found a significant RATe of mortality, apparent ANOMALIES, abnormal torsion, shrinkage of skin and subcutaneous bleeding in FETUSes of RATs receiving high doses of CAFFEINE or a combination of CAFFEINE and CLOMIPRAMINE. Statistical analysis of the data revealed a significant increase (P£0.001) in TERATOGENicity of high doses of CAFFEINE and its combination with CLOMIPRAMINE.Conclusion: This study implies simultaneous intake of high amounts of CAFFEINE and CLOMIPRAMINE lead to TERATOGENicity. We recommend pregnant women to avoid uncontrolled consumption of foods that contain CAFFEINE or drugs that contain high amounts of this substance. They should not also take CLOMIPRAMINE with CAFFEINE in the first trimester of pregnancy.

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APA: Copy

TAKZARE, NASRIN, NIKOUI, VAHID, OSTADHADI, SATTAR, NABAVI, SEYYED MOHAMMAD ALI, & BAKHTIARIAN, AZAM. (2012). TERATOGENIC EFFECTS OF CAFFEINE AND CLOMIPRAMINE ON RAT FETUS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 70(6), 0-0. SID. https://sid.ir/paper/393870/en

Vancouver: Copy

TAKZARE NASRIN, NIKOUI VAHID, OSTADHADI SATTAR, NABAVI SEYYED MOHAMMAD ALI, BAKHTIARIAN AZAM. TERATOGENIC EFFECTS OF CAFFEINE AND CLOMIPRAMINE ON RAT FETUS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2012;70(6):0-0. Available from: https://sid.ir/paper/393870/en

IEEE: Copy

NASRIN TAKZARE, VAHID NIKOUI, SATTAR OSTADHADI, SEYYED MOHAMMAD ALI NABAVI, and AZAM BAKHTIARIAN, “TERATOGENIC EFFECTS OF CAFFEINE AND CLOMIPRAMINE ON RAT FETUS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 70, no. 6, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/393870/en

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