Adolescent morphine exposure increases the intensity of withdrawal syndrome and conditioned place aversion in adulthood

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Sabuee Sara; Ahmadi Soleimani Seyed Mohammad; AZIZI HOSEIN

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY Year:2020 | Volume:4 | Issue:1 (13) Page(s): 19-27

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Information Journal Paper

Title

Adolescent morphine exposure increases the intensity of withdrawal syndrome and conditioned place aversion in adulthood

Author(s)

Sabuee Sara | Ahmadi Soleimani Seyed Mohammad | AZIZI HOSEIN | Issue Writer Certificate

Keywords

Conditioned place aversion

Morphine withdrawal syndrome

Rat

Adolescence

Abstract

Background and aims: Adolescence is considered as a critical developmental period during which long-lasting changes occur in the brain. Accumulating evidence support the growing non-medical use of morphine during Adolescence. However, the long-term neurobiological and behavioral effects of opiate exposure during this stage are still remained largely unexplored. The present study examined the long term effects of adolescent morphine exposure on withdrawal signs and the negative motivational aspects of Morphine withdrawal syndrome induced by naloxone in adult morphine dependent Rats. Methods: Adolescent male Wistar Rats (30 days old) were administered increasing doses of morphine (from 2. 5 to 25 mg/kg, s. c. ) every 12 h, for 10days. Control Rats received saline with the same protocol. Thereafter, during adulthood (65 days old), they were rendered dependent on morphine and tested for opioid withdrawal-induced Conditioned place aversion to investigate the negative motivational aspects of withdrawal syndrome induced by naloxone. Results: Results showed that adolescent morphine treatment significantly increases the expression of morphine withdrawal signs and potentiates naloxone-induced Conditioned place aversion in adult morphine dependent Rats. Conclusion: It can be concluded that chronic morphine treatment during Adolescence in Rats causes prolonged behavioral (and most probably neurobiological) changes in the central nervous system, which results in alteRation of morphine withdrawal in adulthood.

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APA: Copy

Sabuee, Sara, Ahmadi Soleimani, Seyed Mohammad, & AZIZI, HOSEIN. (2020). Adolescent morphine exposure increases the intensity of withdrawal syndrome and conditioned place aversion in adulthood. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 4(1 (13) ), 19-27. SID. https://sid.ir/paper/394042/en

Vancouver: Copy

Sabuee Sara, Ahmadi Soleimani Seyed Mohammad, AZIZI HOSEIN. Adolescent morphine exposure increases the intensity of withdrawal syndrome and conditioned place aversion in adulthood. IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2020;4(1 (13) ):19-27. Available from: https://sid.ir/paper/394042/en

IEEE: Copy

Sara Sabuee, Seyed Mohammad Ahmadi Soleimani, and HOSEIN AZIZI, “Adolescent morphine exposure increases the intensity of withdrawal syndrome and conditioned place aversion in adulthood,” IRANIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 4, no. 1 (13) , pp. 19–27, 2020, [Online]. Available: https://sid.ir/paper/394042/en

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