EFFECT OF HELICOBACTER PYLORI COLONIZATION ON ENTEROCHROMAFFIN-LIKE (ECL) CELL AND GASTRIN (G) POSITIVE CELLS IN RAT STOMACH

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZAEE MOHAMMAD ALI; REZAEI MOHAMMAD JAFAR; RAHMANI MOHAMMAD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2014 | Volume:32 | Issue:296 Page(s): 0-0

Download Full-Text

Persian Verion

View:

1,507

Download:

Cites:

Information Journal Paper

Title

EFFECT OF HELICOBACTER PYLORI COLONIZATION ON ENTEROCHROMAFFIN-LIKE (ECL) CELL AND GASTRIN (G) POSITIVE CELLS IN RAT STOMACH

Author(s)

REZAEE MOHAMMAD ALI | REZAEI MOHAMMAD JAFAR | RAHMANI MOHAMMAD REZA | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

ENTEROCHROMAFFIN-LIKE (ECL) CELLSQ2

GASTRIN PRODUCING (G) CELLQ2

IMMUNOHISTOCHEMISTRY (IHC)Q2

Abstract

Background: Enterochromaffin-like (ECL) cells have an important role in the gastric tissues. HELICOBACTER PYLORI (H.pylori) colonization has effect on function and the number of these cells. The aim of this study was to investigate the effect of 20 weeks H. pylori colonization on ECL and gastrin (G) positive cells in rat gastric tissues.Methods: In this study, 10 rats in two experimental and control groups were divided equally. Then H. pylori and PBS were gavaged to experimental and control groups three times a week for 20 weeks, respectively. Bacterial colonization and histopathological features of gastric tissues were examined with hematoxylin-eosin and Giemsa stains. ECL and G cells were investigated in gastric tissues with silver staining and Immunohistochemistry (IHC) methods.Findings: After 20 weeks gavage, H. pylori colonization was seen in the gastric tissues. Histopathological changes including epithelial disorganization, epithelial vacuolization, lamina propria and epithelium irregularities in the experimental group were seen. Silver staining showed that the mean number of ECL cells were 11.76±1.79 and 8.35±1.34 cells/volume unit in experimental and control groups, respectively (p<0.001). Immunohistochemistry staining showed that mean number of G cells were 6.74±1.21 and 3.65 ±0.084 cells/ volume unit in experimental and control groups, respectively (p<0.001).Conclusion: This study showed that colonization of H. pylori induces epithelial disorganization and vacuolization, lamina propria and epithelium irregularities in gastric tissues and also increases the number of ECL and G cells in these tissues.

Cites

No record.

References

Cite

APA: Copy

REZAEE, MOHAMMAD ALI, REZAEI, MOHAMMAD JAFAR, & RAHMANI, MOHAMMAD REZA. (2014). EFFECT OF HELICOBACTER PYLORI COLONIZATION ON ENTEROCHROMAFFIN-LIKE (ECL) CELL AND GASTRIN (G) POSITIVE CELLS IN RAT STOMACH. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 32(296), 0-0. SID. https://sid.ir/paper/394186/en

Vancouver: Copy

REZAEE MOHAMMAD ALI, REZAEI MOHAMMAD JAFAR, RAHMANI MOHAMMAD REZA. EFFECT OF HELICOBACTER PYLORI COLONIZATION ON ENTEROCHROMAFFIN-LIKE (ECL) CELL AND GASTRIN (G) POSITIVE CELLS IN RAT STOMACH. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;32(296):0-0. Available from: https://sid.ir/paper/394186/en

IEEE: Copy

MOHAMMAD ALI REZAEE, MOHAMMAD JAFAR REZAEI, and MOHAMMAD REZA RAHMANI, “EFFECT OF HELICOBACTER PYLORI COLONIZATION ON ENTEROCHROMAFFIN-LIKE (ECL) CELL AND GASTRIN (G) POSITIVE CELLS IN RAT STOMACH,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 32, no. 296, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/394186/en

Related Journal Papers