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Information Journal Paper

Title

The effect of Menaquinone-4 administration on the expression of pro-inflammatory factors following transient global cerebral ischemia/reperfusion in the hippocampus of male Wistar rat

Pages

  115-122

Abstract

 Introduction: Many investigations revealed that the inflammatory process induced by cerebral ischemia/reperfusion causes brain damages and cognitive impairments. On the other hand, Menaquinone-4 (MK-4) is one of the important vitamin K2 types that has anti-inflammatory effects. Therefore, in this study, we investigated the effect of administration of MK-4 on the level of gene expression of pro-inflammatory cytokines following global ischemia/reperfusion in the hippocampus of male Wistar rats. Materials and Methods: In this research, 20 adult male Wistar rats (250-300 g) were randomly selected in 5 experimental groups and studied: control (intact), sham (surgery without carotid artery occlusion), ischemia/reperfusion, ischemia/reperfusion + intraperitoneal (i. p. ) injection of DMSO as MK-4 solvent, treatment (ischemia/reperfusion + i. p. injection of MK-4). For induction ischemic model, common carotid occlusion was performed for 20 minutes. In the treatment group i. p. injection of 200 mg/kg MK-4 was done 20 minutes after obstruction (immediately and 2 hours after reperfusion). 24 hours after reperfusion, mRNA expression level of TNF-α , IL-1β and IL-6 were assessed. Results: I. p. administration of MK-4 could significantly decrease mRNA expression level of TNF-α (P<1. 15), IL-1β and IL-6 (P<0. 001) induced by ischemia/reperfusion. Conclusion: The findings of this study show that MK-4 administration following cerebral ischemia/reperfusion could diminish the expression of the pro-inflammatory factors in the hippocampus and maybe cause neuroprotective effects.

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    APA: Copy

    FARHADI MOGHADDAM, BAHRAM, & FEREIDONI, MASOUD. (2021). The effect of Menaquinone-4 administration on the expression of pro-inflammatory factors following transient global cerebral ischemia/reperfusion in the hippocampus of male Wistar rat. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 28(1 ), 115-122. SID. https://sid.ir/paper/394735/en

    Vancouver: Copy

    FARHADI MOGHADDAM BAHRAM, FEREIDONI MASOUD. The effect of Menaquinone-4 administration on the expression of pro-inflammatory factors following transient global cerebral ischemia/reperfusion in the hippocampus of male Wistar rat. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(1 ):115-122. Available from: https://sid.ir/paper/394735/en

    IEEE: Copy

    BAHRAM FARHADI MOGHADDAM, and MASOUD FEREIDONI, “The effect of Menaquinone-4 administration on the expression of pro-inflammatory factors following transient global cerebral ischemia/reperfusion in the hippocampus of male Wistar rat,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 1 , pp. 115–122, 2021, [Online]. Available: https://sid.ir/paper/394735/en

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