Aerobic Exercise versus Fluoxetine: The Effect on Depression and Cardiac M2 Muscarinic Receptors in Wistar Rats

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Kohneshin Behzad; Piree Maghsod; MATIN HOMAEE HASAN

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Journal: Sport Physiology and Management Investigations Year:2020 | Volume:12 | Issue:2 Page(s): 131-144

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Information Journal Paper

Title

Aerobic Exercise versus Fluoxetine: The Effect on Depression and Cardiac M2 Muscarinic Receptors in Wistar Rats

Author(s)

Kohneshin Behzad | Piree Maghsod | MATIN HOMAEE HASAN | Issue Writer Certificate

Keywords

Forced Swimming TestQ1

DepressionQ3

Endurance ExerciseQ2

FluoxetineQ1

M2 Muscarinic ReceptorQ1

Abstract

Prolonged exposure to Depression can cause heart failure. The aim of this study was to investigate the effect of endurance aerobic exercise and Fluoxetine administration on Depression and cardiac M2 Muscarinic Receptors in Wistar rats. In this experimental study, 56 Wistar rats (3 months old, mean weight of 220± 15 g) were divided into 7 groups. The exercise group performed 4 weeks of Endurance Exercise on a treadmill with 20 m/min speed, which was equal to 65-80% VO2 max for 45 minutes per day and 6 days a week. The Fluoxetine group received 5 mg of Fluoxetine per kg of body weight. Intraperitoneal injection of lipopolysaccharide was used to depress the rats. The results were analyzed by dependent and independent t tests and ANOVA at the significance level of P<0. 05. Level of Depression in depressed-Fluoxetine group did not significantly change (P=0. 01). The level of Depression was significantly different in the exercisedepressed group (P<0. 05). There was no significant difference in the mean density of M2 Muscarinic Receptors between exercise and exercise-Fluoxetine groups and control group (P=0. 08). There was a significant difference in the mean of exercise-depressed, Fluoxetine-depressed, depressed and exercise-depressed-Fluoxetine groups (P=0. 01). Untreated Depression can worsen Depression symptoms. Depression causes significant changes in the density of M2 Muscarinic Receptors in the heart of rats. Exercise and concomitant administration of Fluoxetine can prevent significant changes in the mean density of cardiac M2 Muscarinic Receptors in depressed rats.

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APA: Copy

Kohneshin, Behzad, Piree, Maghsod, & MATIN HOMAEE, HASAN. (2020). Aerobic Exercise versus Fluoxetine: The Effect on Depression and Cardiac M2 Muscarinic Receptors in Wistar Rats. SPORT PHYSIOLOGY & MANAGEMENT INVESTIGATIONS, 12(2 ), 131-144. SID. https://sid.ir/paper/394953/en

Vancouver: Copy

Kohneshin Behzad, Piree Maghsod, MATIN HOMAEE HASAN. Aerobic Exercise versus Fluoxetine: The Effect on Depression and Cardiac M2 Muscarinic Receptors in Wistar Rats. SPORT PHYSIOLOGY & MANAGEMENT INVESTIGATIONS[Internet]. 2020;12(2 ):131-144. Available from: https://sid.ir/paper/394953/en

IEEE: Copy

Behzad Kohneshin, Maghsod Piree, and HASAN MATIN HOMAEE, “Aerobic Exercise versus Fluoxetine: The Effect on Depression and Cardiac M2 Muscarinic Receptors in Wistar Rats,” SPORT PHYSIOLOGY & MANAGEMENT INVESTIGATIONS, vol. 12, no. 2 , pp. 131–144, 2020, [Online]. Available: https://sid.ir/paper/394953/en

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