Anti scelorotic Effect of Hydroalcoholic Extract of verbascum thapsus, Lemon Peel and Juice and Quinacrine on Blood Lipids, C-Reactive Protein and Phospholipase A2 Activity in MaleWistar Rats

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RAJAEE M.; SHAHANIPOUR K.; MONAJEMI R.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2019 | Volume:21 | Issue:5 Page(s): 308-318

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Title

Anti scelorotic Effect of Hydroalcoholic Extract of verbascum thapsus, Lemon Peel and Juice and Quinacrine on Blood Lipids, C-Reactive Protein and Phospholipase A2 Activity in MaleWistar Rats

Author(s)

RAJAEE M. | SHAHANIPOUR K. | MONAJEMI R. | Issue Writer Certificate

Keywords

QuinacrineQ1

C-reactive proteinQ2

Lipid profileQ2

HypercholesterolemiaQ2

Phospholipase A2Q1

verbascum thapsusQ1

LemonQ1

Abstract

Introduction: Atherosclerosis is a disease of the veins characterized by the deposition of lowdensity lipoprotein (LDL) cholesterol and total cholesterol on the inner wall of medium and large diameter arteries. The aim of this study was to compare the anti-sclerotic effect of hydroalcoholic extract of verbascum thapsus, Lemon juice, Lemon peel and Quinacrine on blood lipid concentration, C-reactive protein (CRP) and Phospholipase A2 (PLA2) enzyme activity in male Wistar rats. Materials and Methods: In this study, 25 male wistar rats were randomly divided into the control (n=5) and high fat diet groups (n=20). After 2 months of a high fat diet, rats with Hypercholesterolemia were divided into 4 groups: receiving 2. 5 ml/kg body weight Lemon juice, 500 mg/kg body weight, Lemon peel, 800 mg/kg body weight hydroalcoholic extract of verbascum thapsus and 6 mg/kg body weight Quinacrine and treated for one month. Finally, the effects of the drug and extracts on Lipid profiles, PLA2 and CRP were evaluated in hypercholesterolemic rats. Results: The high-fat diet increased triglycerides, total cholesterol, and LDL levels and decreased high-density lipoprotein. Administration of hydroalcoholic extract of verbascum thapsus, Lemon peel and juiceand Quinacrine improved lipid status and decreased phospholipaseA2, CRP activity (P<0. 05). Conclusion: Treatment with hydroalcoholic extract of verbascum thapsus, Lemon peel and juice and Quinacrine can improve lipid concentrations, CRP and phospholipaseA2 activity.

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APA: Copy

RAJAEE, M., SHAHANIPOUR, K., & MONAJEMI, R.. (2019). Anti scelorotic Effect of Hydroalcoholic Extract of verbascum thapsus, Lemon Peel and Juice and Quinacrine on Blood Lipids, C-Reactive Protein and Phospholipase A2 Activity in MaleWistar Rats. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 21(5 ), 308-318. SID. https://sid.ir/paper/395003/en

Vancouver: Copy

RAJAEE M., SHAHANIPOUR K., MONAJEMI R.. Anti scelorotic Effect of Hydroalcoholic Extract of verbascum thapsus, Lemon Peel and Juice and Quinacrine on Blood Lipids, C-Reactive Protein and Phospholipase A2 Activity in MaleWistar Rats. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2019;21(5 ):308-318. Available from: https://sid.ir/paper/395003/en

IEEE: Copy

M. RAJAEE, K. SHAHANIPOUR, and R. MONAJEMI, “Anti scelorotic Effect of Hydroalcoholic Extract of verbascum thapsus, Lemon Peel and Juice and Quinacrine on Blood Lipids, C-Reactive Protein and Phospholipase A2 Activity in MaleWistar Rats,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 21, no. 5 , pp. 308–318, 2019, [Online]. Available: https://sid.ir/paper/395003/en

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