LIPID PROFILE CHANGES AFTER LEPTIN ADMINISTRATION: ANIMAL STUDT

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FESHARAKI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2001 | Volume:6 | Issue:3 Page(s): 254-255

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Information Journal Paper

Title

LIPID PROFILE CHANGES AFTER LEPTIN ADMINISTRATION: ANIMAL STUDT

Author(s)

FESHARAKI M. | Issue Writer Certificate

Keywords

FATTY STREAKSQ4

LEPTINQ4

LOW DENSITY LIPOPROTEIN (LDL)Q3

HIGH DENSITY LIPOPROTEIN (HDL)Q3

LEPTINQ4

Abstract

Introduction. Various factors affect on the incidence of atherosclerosis, that most important of them is the high plasma concentration of cholestrol in the form of low density lipoproteins (LDL). This study evaluated the effect of LEPTIN (the product of the ob gene) on the cholesterol, triglyceride, LDL and HDL plasma level. Fatty streak induced hypercholestrolemia in rabbit was studied.Methods. Rabbits were divided to six groups and feeded as followed. Group one: regular diet, 2nd group: high cholestrol diet (HCD), 3rd group: regular diet +leptin 0.1 mg/kg/day, 4th group: HCD + LEPTIN 0.1 mg/kg/day, 5th group: HCD+leptin 1 mg/kg/day and 6th group: HCD+leptin 10 mg/kg/day. Blood samples were taken before and after the study and the plasma level of cholestrol, triglycerid, LDL, HOL and blood pressure was measured. Arterial wall was histopathologically on aorta.Results. The plasma level of cholestrol, triglycerid, LDL, HDL in all HCD group showed significant increasing. LDL between 4th and 6th group had no difference (P>0.05). Fatty steaks in all HCD groups were equal.Discussion. According to the results, we suggest that doses of 0.1, 1 and 10 mg/kg/day of LEPTIN in a short period (30 day), increase the plasma level of LDL, but it have not any effect on the mean blood pressure, plasma level of cholesterol, triglycerid and HDL in rabbit.

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APA: Copy

FESHARAKI, M.. (2001). LIPID PROFILE CHANGES AFTER LEPTIN ADMINISTRATION: ANIMAL STUDT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 6(3), 254-255. SID. https://sid.ir/paper/395124/en

Vancouver: Copy

FESHARAKI M.. LIPID PROFILE CHANGES AFTER LEPTIN ADMINISTRATION: ANIMAL STUDT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2001;6(3):254-255. Available from: https://sid.ir/paper/395124/en

IEEE: Copy

M. FESHARAKI, “LIPID PROFILE CHANGES AFTER LEPTIN ADMINISTRATION: ANIMAL STUDT,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 6, no. 3, pp. 254–255, 2001, [Online]. Available: https://sid.ir/paper/395124/en

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