Fabrication of polymeric microneedle arrays containing amphotericin-B for transdermal drug delivery

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Shojaedin Givi Behnaz; KHAMESIPOUR ALI; Naderimanesh Hossein

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Journal: Dermatology and Cosmetics Year:2019 | Volume:10 | Issue:2 Page(s): 61-68

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Title

Fabrication of polymeric microneedle arrays containing amphotericin-B for transdermal drug delivery

Author(s)

Shojaedin Givi Behnaz | KHAMESIPOUR ALI | Naderimanesh Hossein | Issue Writer Certificate

Keywords

transdermal drug deliveryQ1

microneedle arraysQ1

amphotericin-BQ1

leishmaniasisQ3

Abstract

Background and Aim: Drug delivery through the microneedle array has been considered as an easy and noninvasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a model in skin infections. Methods: In this study, microneedles were fabricated by three-step molding method, which included master mold making, polymeric matrix that blending of polyvinyl pyrrolidine and methacrylic acid and finally casting. Results: The identification of amphotericin-B in polymeric microscopic compositions was investigated by absorption and emission spectroscopy. Also, the mechanical strength of microneedles, which confirms their ability to penetrate the skin, was investigated by a transducer. Conclusion: In this study, the design and fabrication of a skin-permeable polymeric microneedle array with biodegradability and biocompatibility characteristics in physiological environment was performed. Using the properties of designed needles, loading of amphotericin-B was used for the treatment of leishmaniasis and skin fungal infections.

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APA: Copy

Shojaedin Givi, Behnaz, KHAMESIPOUR, ALI, & Naderimanesh, Hossein. (2019). Fabrication of polymeric microneedle arrays containing amphotericin-B for transdermal drug delivery. DERMATOLOGY AND COSMETIC, 10(2 ), 61-68. SID. https://sid.ir/paper/395460/en

Vancouver: Copy

Shojaedin Givi Behnaz, KHAMESIPOUR ALI, Naderimanesh Hossein. Fabrication of polymeric microneedle arrays containing amphotericin-B for transdermal drug delivery. DERMATOLOGY AND COSMETIC[Internet]. 2019;10(2 ):61-68. Available from: https://sid.ir/paper/395460/en

IEEE: Copy

Behnaz Shojaedin Givi, ALI KHAMESIPOUR, and Hossein Naderimanesh, “Fabrication of polymeric microneedle arrays containing amphotericin-B for transdermal drug delivery,” DERMATOLOGY AND COSMETIC, vol. 10, no. 2 , pp. 61–68, 2019, [Online]. Available: https://sid.ir/paper/395460/en

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