Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27

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NAZEMI SAMAD; GOLMOHAMMADI RAHIM; Naeemipour Mohsen; MOJADADI MOHAMMAD SHAFI

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:29 | Issue:179 Page(s): 18-27

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Title

Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27

Author(s)

NAZEMI SAMAD | GOLMOHAMMADI RAHIM | Naeemipour Mohsen | MOJADADI MOHAMMAD SHAFI | Issue Writer Certificate

Keywords

IL-27Q1

experimental autoimmune encephalomyelitisQ2

Multiple sclerosisQ2

IL-17Q1

IFN-γQ1

IL-6Q2

IL-10Q2

regulatory T cellsQ1

Abstract

Background and purpose: In Multiple sclerosis (MS) and its murine model, experimental autoimmune encephalomyelitis (EAE), chronic inflammation damages the myelin of central nervous system. Recently, interleukin-27 (IL-27) has been recognized as a feasible choice for treatment of autoimmune diseases such as MS due to its anti-inflammatory properties. However, the underlying mechanisms have not yet been specified clearly. The present study, investigated the immunomdulatory effects of IL-27 in C57BL/6 mice with EAE. Materials and methods: In this experimental study, two groups of EAE mice (test and control groups) received intraperitoneal injection of P240-mIL-27 (200 μ g) and P240 plasmid (200 μ g), respectively. The disease severity was evaluated daily for 30 days. At the end of the treatment period, the mice were sacrificed and the levels of IL-17, IFN-γ , IL-6, and IL-10 were measured in splenocytes culture media using ELISA method. Also, the percentage of CD4+Foxp3+ regulatory T cells (Treg) in spleen cells was analyzed using flow cytometry. Results: Severity of EAE significantly decreased in test group (P240-mIL27), compared to that of the control group. In test group, the levels of IL-17, IFN-γ , and IL-6 were significantly lower (P<0. 001), while IL-10 levels were significantly higher compared to those of the control group (P<0. 001). Moreover, the percentage of Treg cells in test group was significantly higher than that of the control mice (P<0. 001). Conclusion: IL-27 can be a suitable choice in treatment of inflammatory diseases such as MS via increasing Treg cells and IL-10, and suppression of inflammatory cytokines.

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APA: Copy

NAZEMI, SAMAD, GOLMOHAMMADI, RAHIM, Naeemipour, Mohsen, & MOJADADI, MOHAMMAD SHAFI. (2019). Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(179 ), 18-27. SID. https://sid.ir/paper/395635/en

Vancouver: Copy

NAZEMI SAMAD, GOLMOHAMMADI RAHIM, Naeemipour Mohsen, MOJADADI MOHAMMAD SHAFI. Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(179 ):18-27. Available from: https://sid.ir/paper/395635/en

IEEE: Copy

SAMAD NAZEMI, RAHIM GOLMOHAMMADI, Mohsen Naeemipour, and MOHAMMAD SHAFI MOJADADI, “Increase in CD4+Foxp3+ Regulatory T cells and Amelioration of Experimental Autoimmune Encephalomyelitis in Mice Treated with IL-27,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 179 , pp. 18–27, 2019, [Online]. Available: https://sid.ir/paper/395635/en

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