Effect of curcumin on plasma membrane integrity and stress oxidative and serum in mice treated with cadmium chloride factors testis

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Chehreii SH.; MOMENI H.R.; Atabaki Z.

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Journal: JOURNAL OF CELL & TISSUE Year:2018 | Volume:9 | Issue:1 Page(s): 1-11

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Title

Effect of curcumin on plasma membrane integrity and stress oxidative and serum in mice treated with cadmium chloride factors testis

Author(s)

Chehreii SH. | MOMENI H.R. | Atabaki Z. | Issue Writer Certificate

Keywords

cadmiumQ1

curcuminQ1

malondialdehydeQ2

plasma membrane integrityQ1

total antioxidant activityQ1

Abstract

Aim: The current research was done to investigate the sperm plasma membrane integrity, oxidative stress factors of sperm and testis in male mice treated with cadmium. Material and Methods: 24 adult NMRI mice were divided into four groups: 1. Control group 2. Treated with cadmium chloride (5 mg/kg) 3. Treated with curcumin (100 mg/kg) 4. Treated with curcumin + cadmium chloride. The treatments were performed as a single dose and after 24 hours, epididymal spermatozoa of different groups were used to evaluate the plasma membrane integrity. In addition, the amount of malondialdehyde (MDA) and the anti-oxidant activity of serum and testis were evaluated. Data were analyzed using ANOVA test followed by Turkey’ s test (p<0. 05). Results: findings showed that cadmium chloride caused a significant decrement in plasma membrane integrity compared to the control groups. In addition, cadmium chloride induced a significant increment of MDA in serum and testis and a significant decrement in total antioxidant activity of serum and testis as compared to the group. In curcumin + cadmium chloride-treated group, curcumin could significantly compensate the toxic effect of cadmium on these parameters compared to the cadmium-treated group. Conclusion: it seems that curcumin as a potent antioxidant is able to ameliorate the adverse effects of cadmium chloride on sperm plasma membrane integrity, lipid oxidation and total antioxidant activity of serum and testis.

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APA: Copy

Chehreii, SH., MOMENI, H.R., & Atabaki, Z.. (2018). Effect of curcumin on plasma membrane integrity and stress oxidative and serum in mice treated with cadmium chloride factors testis. JOURNAL OF CELL & TISSUE, 9(1 ), 1-11. SID. https://sid.ir/paper/395957/en

Vancouver: Copy

Chehreii SH., MOMENI H.R., Atabaki Z.. Effect of curcumin on plasma membrane integrity and stress oxidative and serum in mice treated with cadmium chloride factors testis. JOURNAL OF CELL & TISSUE[Internet]. 2018;9(1 ):1-11. Available from: https://sid.ir/paper/395957/en

IEEE: Copy

SH. Chehreii, H.R. MOMENI, and Z. Atabaki, “Effect of curcumin on plasma membrane integrity and stress oxidative and serum in mice treated with cadmium chloride factors testis,” JOURNAL OF CELL & TISSUE, vol. 9, no. 1 , pp. 1–11, 2018, [Online]. Available: https://sid.ir/paper/395957/en

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