Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart Surgery

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ALIAN SHAHRIAR; VALEDSARAVI TOKTAM SADAT; AHANGARKANI FATEMEH; DAVOUDI ALIREZA; NAJAFI NARGES; ARABI MOHSEN

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:29 | Issue:180 Page(s): 46-56

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Title

Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart Surgery

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Keywords

Staphylococcus aureusQ2

mupirocinQ2

open-heart surgeryQ3

nosocomial infectionQ2

Abstract

Background and purpose: Surgical site infection is one of the most important complications of cardiac surgery, and in 50% of cases, is caused by Staphylococcus species. This study evaluated the effectiveness of intranasal administration of mupirocin in reducing nasal bacterial colonization, mediastinal, sternal, pulmonary, and skin infections after open-heart surgery. Materials and methods: This descriptive study investigated the records of patients who developed post-operative infection following open-heart surgery in Sari Fatemeh Zahra Hospital during 2011-2015. Treatments were done in two different periods: first period from 2011 to September 2013 and the second period from October 2013 to March 2015. In second course, intra-nasal administration of mupirocin was done to all patients, as a routine hospital care. Then, the incidence of post-operative infection, type, and site of infection were compared. Results: Frequency of infection was 78. 26% in the group that had recieved mupirocin and 46. 29% in the group that had not received mupirocin. The rate of surgical site infection in the group that had received mupirocin was 21. 74% and in the group without mupirocin it was 53. 71% (P= 0. 000). We observed significant reductions in the incidence of superficial infection of the incision (1. 85% in the group that was given mupirocin vs. 10. 9% in the group without mupirocin, P= 0. 009), foot superficial infections (23. 1% in the group that had received mupirocin vs. 27. 7% in the group without mupirocin, P= 037), and deep soft tissue infection of foot (10. 3% in the group that had received mupirocin and 18. 18% in the group that had nor received mupirocin). Conclusion: Intra-nasal administration of mupirocin could prevent cutaneous infections after cardiac surgery and also reduce hospital length of stay.

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APA: Copy

ALIAN, SHAHRIAR, VALEDSARAVI, TOKTAM SADAT, AHANGARKANI, FATEMEH, DAVOUDI, ALIREZA, NAJAFI, NARGES, & ARABI, MOHSEN. (2020). Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart Surgery. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(180 ), 46-56. SID. https://sid.ir/paper/396011/en

Vancouver: Copy

ALIAN SHAHRIAR, VALEDSARAVI TOKTAM SADAT, AHANGARKANI FATEMEH, DAVOUDI ALIREZA, NAJAFI NARGES, ARABI MOHSEN. Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart Surgery. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(180 ):46-56. Available from: https://sid.ir/paper/396011/en

IEEE: Copy

SHAHRIAR ALIAN, TOKTAM SADAT VALEDSARAVI, FATEMEH AHANGARKANI, ALIREZA DAVOUDI, NARGES NAJAFI, and MOHSEN ARABI, “Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart Surgery,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 180 , pp. 46–56, 2020, [Online]. Available: https://sid.ir/paper/396011/en

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