THE RELATIONSHIP BETWEEN HEMOGLOBIN LEVEL WITH PTH LEVEL AND DIALYSISADEQUACY IN CHRONIC HEMODIALYSIS PATIENTS

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AGHSAIEFARD ZIBA; HOSSENIFARD ZIBA; ALIZADEH REZA; RAMIM TAYEB

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Journal: Tehran University Medical Journal Year:2018 | Volume:76 | Issue:4 Page(s): 257-264

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Title

THE RELATIONSHIP BETWEEN HEMOGLOBIN LEVEL WITH PTH LEVEL AND DIALYSISADEQUACY IN CHRONIC HEMODIALYSIS PATIENTS

Author(s)

AGHSAIEFARD ZIBA | HOSSENIFARD ZIBA | ALIZADEH REZA | RAMIM TAYEB | Issue Writer Certificate

Keywords

DIALYSISQ3

HEMOGLOBINQ3

HEMATOCRITQ3

PARATHYROID HORMONEQ2

Abstract

Background: The role of high levels of PARATHYROID HORMONE in the development ofanemia either directly or by mediating mechanisms is unclear, and there is acontroversy about the pathophysiological role of PARATHYROID HORMONE (PTH) in thedevelopment and intensification of anemia associated with renal disease. The aim ofthis study was to investigate the relationship between anemia and PARATHYROID HORMONEand DIALYSIS adequacy in chronic hemoDIALYSIS patients. Methods: A cross-sectional study was performed in patients undergoing DIALYSIS inSoodeh HemoDIALYSIS Center, Vavan city, Tehran province, Iran, in two years(September 2013 to September 2015). Patients with age>18 years who underwentDIALYSIS for at least three months were enrolled. Anemia was calculated based on theabsolute amount of HEMOGLOBIN, HEMATOCRIT, and the percentage of patients whoachieved the HEMOGLOBIN treatment goal of more than 11 g/dL. PARATHYROID HORMONElevels were measured intact PTH and enzyme immunoassay (EIA) method. Results: 176 patients who had entry criteria participated in this study. Patients included102 males (58%) and 74 women (42%). The mean age of the patients was 54. 14± 13. 98years (18-85 years). The mean weight of patients was 68. 07± 14. 17 kg (36-120 kg). 23(13. 1%) of the patients had a previous history of kidney transplantation. Of the 176patients, only one had a history of parathyroidectomy (0. 6%). The mean DIALYSIS time inthe patients was 6. 38± 5. 29 years (1-28 years). The type of DIALYSIS access in 132patients (75%) was AV fistula and in 44 patients (25%) was Shaldon catheter. Themean erythropoietin intake of patients was 10, 000 units per week. The mean ofhemoglobin, HEMATOCRIT and PTH were 10. 73 g/dl 33. 6% and 403 pg/ml, respectively. Conclusion: The findings of the study showed that there was no significant correlationbetween HEMOGLOBIN and HEMATOCRIT levels with PARATHYROID HORMONE levels andDIALYSIS adequacy. Increased levels of serum iron, total iron binding capacity (TIBC)and resistance to erythropoietin were associated with a decrease in HEMATOCRIT levelsdue to decreased HEMOGLOBIN levels and resistance to erythropoietin.

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APA: Copy

AGHSAIEFARD, ZIBA, HOSSENIFARD, ZIBA, ALIZADEH, REZA, & RAMIM, TAYEB. (2018). THE RELATIONSHIP BETWEEN HEMOGLOBIN LEVEL WITH PTH LEVEL AND DIALYSISADEQUACY IN CHRONIC HEMODIALYSIS PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(4 ), 257-264. SID. https://sid.ir/paper/39622/en

Vancouver: Copy

AGHSAIEFARD ZIBA, HOSSENIFARD ZIBA, ALIZADEH REZA, RAMIM TAYEB. THE RELATIONSHIP BETWEEN HEMOGLOBIN LEVEL WITH PTH LEVEL AND DIALYSISADEQUACY IN CHRONIC HEMODIALYSIS PATIENTS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(4 ):257-264. Available from: https://sid.ir/paper/39622/en

IEEE: Copy

ZIBA AGHSAIEFARD, ZIBA HOSSENIFARD, REZA ALIZADEH, and TAYEB RAMIM, “THE RELATIONSHIP BETWEEN HEMOGLOBIN LEVEL WITH PTH LEVEL AND DIALYSISADEQUACY IN CHRONIC HEMODIALYSIS PATIENTS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 4 , pp. 257–264, 2018, [Online]. Available: https://sid.ir/paper/39622/en

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