STUDY OF HER2/NEU PROTEIN OVER EXPRESSION FREQUENCY AND ITS RELATIONSHIP WITH GRADE, STAGE IN PATIENTS WITH NON METATSTATIC TRANSITIONAL CELL CARCINOMA AND DISEASE FREE SURVIVAL

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SAEIDI SAEDI HAMID; TAVAKOLI TABASI K.; MOHAMMADIAN ROUSHAN N.; SHAKERI M.T.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:18 | Issue:69 Page(s): 1-5

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Title

STUDY OF HER2/NEU PROTEIN OVER EXPRESSION FREQUENCY AND ITS RELATIONSHIP WITH GRADE, STAGE IN PATIENTS WITH NON METATSTATIC TRANSITIONAL CELL CARCINOMA AND DISEASE FREE SURVIVAL

Author(s)

SAEIDI SAEDI HAMID | TAVAKOLI TABASI K. | MOHAMMADIAN ROUSHAN N. | SHAKERI M.T. | Issue Writer Certificate

Keywords

CARCINEMAQ3

TRANSITIONAL CELLQ3

DISEASE FREE SURVIVALQ3

HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIESQ3

Abstract

Introduction: HER2 over-expression has been identified in a variety of malignant tumors including bladder transitional carcinoma. In some researches HER2 was detected in 10%-50% of muscle invasive bladder cancers. In this study we evaluated the correlation between HER2 over-expression and pathological characteristics as well as its impact on the DISEASE FREE SURVIVAL (DFS) of patients with non-metastatic bladder transitional carcinoma.Objective: Study of Her2/neu Protein over Expression Frequency and Its Relationship with Grade, Stage in Patients with Non Metatstatic TRANSITIONAL CELL Carcinoma and DISEASE FREE SURVIVAL.Materials and Methods: In this retrospective cohort study, paraffin-embedded specimens from 50 patients with non-metastatic bladder TRANSITIONAL CELL carcinoma, referred to Omid hospital from 2003 to 2007, were examined immunohistochemically for HER-2/neu over-expression. The specimens were also reviewed for tumor grade. The patients with superficial tumors underwent TURBT and a full course of intravesical BCG therapy and cases with muscle invasive tumor received cisplatin based chemoradiation. Results: There were 27 (54%) high grade and 23 low grade tumors. The specimens stained for HER-2 over-expression as follow: 11 as Zero, 11 as 1+, 13 as 2+ and 15 as 3+. The T stages of Tis, T1, T2 and T3 were detected in 14, 19, 10, and 7 cases respectively. The frequency of strong positive HER-2 tumors (3+) was significantly higher among patients with muscle invasive tumors compared to those with superficial lesions (58.8% vs. 15.2%, p<0.001). There was also a relatively significant association between strong positive HER-2 expression and high grade tumors (43.5% vs. 18.5% p=0.055). The Median follow up time was 14 months (range, 4-52 months) during which 17 cases (34%) experienced recurrence (12 local, 3 bones & 2 lungs). For all patients 3-year DFS was 62.7%±7.4% which was significantly better for cases with superficial tumors than patients with muscle invasive tumors (78.1% vs. 19.5%, p=0.005). In patients with strong positive HER-2 expression tumors, DFS was significantly lower compared to the other cases (3-year DFS: 19.4% vs. 80%, p<0.001). No significant difference in DFS was found between high grade and low grade tumors (3-DFS: 53.9% vs. 70%, p=0.20). Conclusion: In This study, strong HER-2 over-expression (3+) was significantly associated with higher T stages as well as high grade tumors. In addition to T stage, strong HER-2 over-expression was a significant predictor of lower DISEASE FREE SURVIVAL.

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APA: Copy

SAEIDI SAEDI, HAMID, TAVAKOLI TABASI, K., MOHAMMADIAN ROUSHAN, N., & SHAKERI, M.T.. (2009). STUDY OF HER2/NEU PROTEIN OVER EXPRESSION FREQUENCY AND ITS RELATIONSHIP WITH GRADE, STAGE IN PATIENTS WITH NON METATSTATIC TRANSITIONAL CELL CARCINOMA AND DISEASE FREE SURVIVAL. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 18(69), 1-5. SID. https://sid.ir/paper/39664/en

Vancouver: Copy

SAEIDI SAEDI HAMID, TAVAKOLI TABASI K., MOHAMMADIAN ROUSHAN N., SHAKERI M.T.. STUDY OF HER2/NEU PROTEIN OVER EXPRESSION FREQUENCY AND ITS RELATIONSHIP WITH GRADE, STAGE IN PATIENTS WITH NON METATSTATIC TRANSITIONAL CELL CARCINOMA AND DISEASE FREE SURVIVAL. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;18(69):1-5. Available from: https://sid.ir/paper/39664/en

IEEE: Copy

HAMID SAEIDI SAEDI, K. TAVAKOLI TABASI, N. MOHAMMADIAN ROUSHAN, and M.T. SHAKERI, “STUDY OF HER2/NEU PROTEIN OVER EXPRESSION FREQUENCY AND ITS RELATIONSHIP WITH GRADE, STAGE IN PATIENTS WITH NON METATSTATIC TRANSITIONAL CELL CARCINOMA AND DISEASE FREE SURVIVAL,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 69, pp. 1–5, 2009, [Online]. Available: https://sid.ir/paper/39664/en

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