COMPARISON OF THE EFFECT OF PROPOFOL AND MIDAZOLAM ON SERUM LEVEL OF CARDIAC TROPONIN T FOLLOWING CORONARY ARTERY BYPASS GRAFT

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IMANTALAB V.; MIRFALAH S.R.; MOHAMMADZADEH ALI; MIRMANSOURI ALI

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Journal: Journal of Guilan University of Medical Sciences Year:2009 | Volume:18 | Issue:69 Page(s): 33-40

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Title

COMPARISON OF THE EFFECT OF PROPOFOL AND MIDAZOLAM ON SERUM LEVEL OF CARDIAC TROPONIN T FOLLOWING CORONARY ARTERY BYPASS GRAFT

Author(s)

IMANTALAB V. | MIRFALAH S.R. | MOHAMMADZADEH ALI | MIRMANSOURI ALI | Issue Writer Certificate

Keywords

CORONARY ARTERY BYPASSQ3

ISCHEMIC PRECONDITIONINGQ2

MIDAZOLAMQ3

PROPOFOLQ3

TROPONIN TQ3

Abstract

Introduction: Cardiac surgery is associated with some degree of myocardial injury. Preconditioning was described first in 1986 and it classified into: pharmacologic and Non-pharmacologic. Volatile Anesthetic agents (Sevofluran) with stimulation of ISCHEMIC PRECONDITIONING can protect myocardium. At least one study has demonstrated the potential salutary effect of volatile anesthetic agents on cardiac TROPONIN T (cTnT) (a reliable marker of myocardial injury). In another study MIDAZOLAM, PROPOFOL and Sevofluran provides equal protection in pediatric cardiac surgery.Objective: To compare the effect of MIDAZOLAM and PROPOFOL on the level of cTnT following CABG.Materials and Methods: In this clinical trial, double blind study 40 elected patients for CABG were randomly assigned to receive infusion of PROPOFOL or MIDAZOLAM. Other surgical procedures and anesthetics were similar for both groups. Serum cTnT was measured preoperatively and at 12, 24 and 36hr post operation.Results: Serum cTnT was significantly raised in both groups. In all postoperative episodes, cTnT concentration intended to be higher in MIDAZOLAM group than PROPOFOL group, but this difference was not significant. The peak levels of cTnT (T12) in both groups were much lower than peak level of cTnT were much lower than peak level of cTnT in previous studies [in previous studies in MIDAZOLAM group T12=0.260 (±0.171) ng/ml–in PROPOFOL group T12=0.205 (±0.110) ng/ml)]. Conclusion: MIDAZOLAM and PROPOFOL provided equal myocardial protection during CABG.

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APA: Copy

IMANTALAB, V., MIRFALAH, S.R., MOHAMMADZADEH, ALI, & MIRMANSOURI, ALI. (2009). COMPARISON OF THE EFFECT OF PROPOFOL AND MIDAZOLAM ON SERUM LEVEL OF CARDIAC TROPONIN T FOLLOWING CORONARY ARTERY BYPASS GRAFT. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 18(69), 33-40. SID. https://sid.ir/paper/39667/en

Vancouver: Copy

IMANTALAB V., MIRFALAH S.R., MOHAMMADZADEH ALI, MIRMANSOURI ALI. COMPARISON OF THE EFFECT OF PROPOFOL AND MIDAZOLAM ON SERUM LEVEL OF CARDIAC TROPONIN T FOLLOWING CORONARY ARTERY BYPASS GRAFT. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;18(69):33-40. Available from: https://sid.ir/paper/39667/en

IEEE: Copy

V. IMANTALAB, S.R. MIRFALAH, ALI MOHAMMADZADEH, and ALI MIRMANSOURI, “COMPARISON OF THE EFFECT OF PROPOFOL AND MIDAZOLAM ON SERUM LEVEL OF CARDIAC TROPONIN T FOLLOWING CORONARY ARTERY BYPASS GRAFT,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 69, pp. 33–40, 2009, [Online]. Available: https://sid.ir/paper/39667/en

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