Effects of Alpha-Lipoid Acid on Serum Iron, Total Iron Binding Capacity and Hematological Indices in β-Thalassemia Major Patients: A Cross Over Clinical Trial

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SHARIFI ZAHABI E.; ABDOLLAHZAD H.; Golpayegani M.R.; JAMSHIDI K.; Asiaei S.; AGHDASHI M.A.; Mohammad Hosseini Azar M.R.; Fallah Pakdel S.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2020 | Volume:15 | Issue:3 Page(s): 9-18

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Title

Effects of Alpha-Lipoid Acid on Serum Iron, Total Iron Binding Capacity and Hematological Indices in β-Thalassemia Major Patients: A Cross Over Clinical Trial

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Keywords

Beta-thalassemiaQ1

Iron overloadQ1

Thioctic acidQ1

Cross-over studyQ1

Abstract

Background and Objectives: Accumulation of iron is the most common consequences of repeated blood transfusions in β-thalassemia major patients. Iron chelating effects of alpha-lipoic acid have been reported by several studies. The aim of this study was to investigate effects of supplementation with alpha-lipoic acid, as a chelator, on serum iron and hematological indices in these patients. Materials & Methods: Twenty-two β-thalassemia major patients were selected to receive 600 mg alpha-lipoic acid or placebo capsules for 8 w. After a 3-week washout period, order of intervention was replaced as patients who previously received placebo were administered the supplement vise versa for another 8 w. At the end of the study, changes in serum iron, total iron binding capacity and hematological parameters between the treatments were assessed. Results: Serum concentrations of iron and total iron binding capacity and hematological parameters did not change within the supplementation (p > 0. 05). Changes in iron, total iron binding capacity and hematological indices were not significantly different between the two interventions (p > 0. 05). White blood cell counts in placebo use increased significantly in males (p = 0. 04). The mean corpuscular hemoglobin in placebo patients decreased significantly in all patients and males (p = 0. 02 for both). Conclusion: Results of this study revealed that alpha-lipoic acid supplementation included no beneficial effects on iron, total iron binding capacity and hematological indices in β-thalassemia major patients. Further studies with more participants and longer times are indispensable.

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APA: Copy

SHARIFI ZAHABI, E., ABDOLLAHZAD, H., Golpayegani, M.R., JAMSHIDI, K., Asiaei, S., AGHDASHI, M.A., Mohammad Hosseini Azar, M.R., & Fallah Pakdel, S.. (2020). Effects of Alpha-Lipoid Acid on Serum Iron, Total Iron Binding Capacity and Hematological Indices in β-Thalassemia Major Patients: A Cross Over Clinical Trial. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 15(3 ), 9-18. SID. https://sid.ir/paper/397164/en

Vancouver: Copy

SHARIFI ZAHABI E., ABDOLLAHZAD H., Golpayegani M.R., JAMSHIDI K., Asiaei S., AGHDASHI M.A., Mohammad Hosseini Azar M.R., Fallah Pakdel S.. Effects of Alpha-Lipoid Acid on Serum Iron, Total Iron Binding Capacity and Hematological Indices in β-Thalassemia Major Patients: A Cross Over Clinical Trial. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2020;15(3 ):9-18. Available from: https://sid.ir/paper/397164/en

IEEE: Copy

E. SHARIFI ZAHABI, H. ABDOLLAHZAD, M.R. Golpayegani, K. JAMSHIDI, S. Asiaei, M.A. AGHDASHI, M.R. Mohammad Hosseini Azar, and S. Fallah Pakdel, “Effects of Alpha-Lipoid Acid on Serum Iron, Total Iron Binding Capacity and Hematological Indices in β-Thalassemia Major Patients: A Cross Over Clinical Trial,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 15, no. 3 , pp. 9–18, 2020, [Online]. Available: https://sid.ir/paper/397164/en

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