Effect of Alcoholic Extracts of Panicum Miliaceum Seed on Hipocampus Dentate Gyrus Neuronal Density in Male Rats

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Borna Roodi Arezoo; TEHRANIPOUR MARYAM; AMINTAHERI NASTARAN

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Journal: Research in Medicine Year:2018 | Volume:42 | Issue:3 Page(s): 126-130

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Title

Effect of Alcoholic Extracts of Panicum Miliaceum Seed on Hipocampus Dentate Gyrus Neuronal Density in Male Rats

Author(s)

Borna Roodi Arezoo | TEHRANIPOUR MARYAM | AMINTAHERI NASTARAN | Issue Writer Certificate

Keywords

Neuronal densityQ1

Millet grainQ2

Dentate gyrusQ1

NeurogenesisQ1

Abstract

Background: In the evolution of brain in different species, the process of neurons formation has been confirmed in some brain areas. This process is known as Neurogenesis. Neurogenesis occurs in two areas of the adult mammals' anterior brain, including regional sub-ventriculus and Dentate gyrus in various species, including rodents, primates and humans. Millet belongs to the family of Poaceae. The seed of this plant has various vitamins and other valuable compounds, such as polyphenols, carbohydrates, and fatty acids. The aim of the present investigation was to examine the effect of alcoholic extracts of grain Millet on Neuronal density of Dentate gyrus of the hippocampus in male rats. Materials and Methods: The current experimental study was conducted on 24 adult male rats. First, the soxhelet of alcoholic extract form the seed of the Panicum miliaceum plant with herbarium code 9738 was prepared. Mice were randomly divided into four groups of control, and treatment with extract doses of 50, 25, and 75 mg/kg. In the treatment groups, the extract, was injected intraperitoneally (IP) continuously for 21 day with an invertal of 24 hours and the control group received normal saline injection. One month after the first injection, the animals were anesthetized and the brains were gently removed from the skall. After processing, seven-micron serial sections were stained with blue toluidine and erythrosine. Then, Dentate gyrus were photographed and Neuronal density of Dentate gyrus in different groups were evaluated using stereological methods and were compared with control groups using the statistical program. Results: In the treatment group with a dose of 25 mg/kg, the Neuronal density of the DG region was significantly increased as compared with that of the control group (P = 0. 001). Also, in the treatment groups with a dose of 50 mg/kg and 75 mg/kg, there was a significant increase in Neuronal density of DG region, as compared with that of the control group (P = 0). Conclusion: The present study showed that the alcoholic extract of the seed of Panicum miliaceum plant can probably increase neurons of the Dentate gyrus of the lab mice. It is likely that alcoholic extracts of Millet grain increased Neurogenesis leading to the increase in the Neuronal density.

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APA: Copy

Borna Roodi, Arezoo, TEHRANIPOUR, MARYAM, & AMINTAHERI, NASTARAN. (2018). Effect of Alcoholic Extracts of Panicum Miliaceum Seed on Hipocampus Dentate Gyrus Neuronal Density in Male Rats. PAJOUHESH DAR PEZESHKI, 42(3 ), 126-130. SID. https://sid.ir/paper/398240/en

Vancouver: Copy

Borna Roodi Arezoo, TEHRANIPOUR MARYAM, AMINTAHERI NASTARAN. Effect of Alcoholic Extracts of Panicum Miliaceum Seed on Hipocampus Dentate Gyrus Neuronal Density in Male Rats. PAJOUHESH DAR PEZESHKI[Internet]. 2018;42(3 ):126-130. Available from: https://sid.ir/paper/398240/en

IEEE: Copy

Arezoo Borna Roodi, MARYAM TEHRANIPOUR, and NASTARAN AMINTAHERI, “Effect of Alcoholic Extracts of Panicum Miliaceum Seed on Hipocampus Dentate Gyrus Neuronal Density in Male Rats,” PAJOUHESH DAR PEZESHKI, vol. 42, no. 3 , pp. 126–130, 2018, [Online]. Available: https://sid.ir/paper/398240/en

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