Comparative Effect of Three Non-Steroidal Anti Inflammatory Drugs on Gene Expression of Myeloperoxidase in Lung and Liver Tissues of Septic Rats

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Salehiyan Hamideh; HAJIHOSSEINI REZA; Rasooli Azadeh; Miri Saba

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Journal: Research in Medicine Year:2019 | Volume:43 | Issue:3 Page(s): 130-135

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Title

Comparative Effect of Three Non-Steroidal Anti Inflammatory Drugs on Gene Expression of Myeloperoxidase in Lung and Liver Tissues of Septic Rats

Author(s)

Salehiyan Hamideh | HAJIHOSSEINI REZA | Rasooli Azadeh | Miri Saba | Issue Writer Certificate

Keywords

SepsisQ3

MyeloproxidaseQ1

Gene expressionQ2

Non-Steroidal Anti-Inflammatory drugsQ1

Abstract

Background: Sepsis is the systemic response of the body to severe infection and one of the causes of mortality in ICU. Considering the importance of Sepsis, in the present study, the effect of Non-Steroidal Anti-Inflammatory (NSAIDs) drugs (aspirin, indometacin, celecoxib) on inflammatory biomarker of myeloperoxidase (MPO) in liver and lung tissues of rats was investigated. Materials and Methods: In the current experimental study, animals were divided into six groups: the control group, the lapratomy (LAP) group, the CLP group, treatment groups: CLP surgery and immediate treatment of rats with NSAIDs (2 mg/kg b. w) once daily. Two days after CLP, the rats were killed and the liver and lung tissues were isolated and the Real-Time PCR technique was used to determine the expression of the MPO gene. Statistical analyses were performed using one-way ANOVA followed by LSD in SPSS (version 19. 0). The significance value was considered as P < 0. 05. Results: The results indicated that the expression of MPO gene in lung and liver tissue of the LAP group increased significantly as compared with control group. The level of expression of the MPO gene in the CLP lung and liver tissue was significantly increased as compared to the LAP group. However, in the treatment groups, a significant decrease in the expression of MPO gene was observed. Although all three drugs had a positive effect on reducing Gene expression (celecoxib>indomethacin>aspirin), in lung tissue, celecoxib had the highest effect and aspirin had the least effect on reducing the expression of MPO gene. In liver tissue, aspirin, and celecoxib, the least effect on reducing Gene expression was observed. Conclusion: It seems that the treatment of animals with selected drugs have the inhibiting effect on the increase of MPO Gene expression and results in reducing the damage to the liver and lung tissue caused by Sepsis.

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APA: Copy

Salehiyan, Hamideh, HAJIHOSSEINI, REZA, Rasooli, Azadeh, & Miri, Saba. (2019). Comparative Effect of Three Non-Steroidal Anti Inflammatory Drugs on Gene Expression of Myeloperoxidase in Lung and Liver Tissues of Septic Rats. PAJOUHESH DAR PEZESHKI, 43(3 ), 130-135. SID. https://sid.ir/paper/398252/en

Vancouver: Copy

Salehiyan Hamideh, HAJIHOSSEINI REZA, Rasooli Azadeh, Miri Saba. Comparative Effect of Three Non-Steroidal Anti Inflammatory Drugs on Gene Expression of Myeloperoxidase in Lung and Liver Tissues of Septic Rats. PAJOUHESH DAR PEZESHKI[Internet]. 2019;43(3 ):130-135. Available from: https://sid.ir/paper/398252/en

IEEE: Copy

Hamideh Salehiyan, REZA HAJIHOSSEINI, Azadeh Rasooli, and Saba Miri, “Comparative Effect of Three Non-Steroidal Anti Inflammatory Drugs on Gene Expression of Myeloperoxidase in Lung and Liver Tissues of Septic Rats,” PAJOUHESH DAR PEZESHKI, vol. 43, no. 3 , pp. 130–135, 2019, [Online]. Available: https://sid.ir/paper/398252/en

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