Evaluation of the healing effect of Psidium Guajava L. hydro-alcoholic fruit extract on induced osteoarthritis in male rats

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Nabavizadeh Sara Sadat; Ahmadi Zarei Mohsen; Iraji Cambyz; IRAJI AIDA; GHAEMMAGHAMI PARVIN; KOOHI HOSSEINABADI OMID; Hasssanpour Ida; Mojahed maryam; DANESHI SAJAD; TANIDEH NADER; Jamshidi Mahshid

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Journal: IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY Year:2019 | Volume:17 | Issue:3 (66) Page(s): 116-125

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Title

Evaluation of the healing effect of Psidium Guajava L. hydro-alcoholic fruit extract on induced osteoarthritis in male rats

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Keywords

OsteoarthritisQ1

KneeQ2

RadiographyQ1

PathologyQ1

Psidium GuajavaQ1

RatsQ1

Abstract

Background: Osteoarthritis is a major public health consideration which leads to disability because of chronic pain, stiffness, sleeping disorder and depression. Among the herbal products Psidium Guajava L. fruit could be regarded as a potential natural remedy due to its anti-oxidant characteristics. The aim of this study was to evaluate the healing effect of Psidium Guajava L. fruit on Osteoarthritis of the Knee in Rats. Methods: Forty male Sprague-Dawley Rats with induced Osteoarthritis by intra-articular injection of 500U of type 2 collagenase in the left Knee were recruited in four treatment groups (n=10): (A) control, (B) Piascledine (10mg/kg) as positive control, (C) oral administration of hydro-alcoholic extract of Psidium Guajava L. fruit (500mg/kg), and (D) oral administration hydro-alcoholic extract of Psidium Guajava L. fruit (1000mg/kg). After 8 weeks of daily administration, the outcome was evaluated by histopathological and radiographic assessments. The data were analyzed using Kruskal-Wallis nonparametric in SPSS version 23. 00, and P<0. 05 was considered statistically significant. Results: Psidium Guajava extract exhibited good radical scavenging activities with IC50 of 0. 46 ± 0. 13 mg/mL (quercetin as a positive control). Histopathological assessments of the cartilage showed smooth and continuous articular surface with columnar cell distribution in the experimental group that received 1000mg/kg Psidium Guajava L. fruit hydro-alcoholic extract which healed better than others, especially in the control group (p-value =0. 02). The radiological assessments of the Knee joints showed similar findings in histopathological assessment. Conclusion: Psidium Guajava L. fruit hydro-alcoholic extract might be regarded as an effective complementary and alternative treatment for Osteoarthritis of the Knee in Rats.

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APA: Copy

Nabavizadeh, Sara Sadat, Ahmadi Zarei, Mohsen, Iraji, Cambyz, IRAJI, AIDA, GHAEMMAGHAMI, PARVIN, KOOHI HOSSEINABADI, OMID, Hasssanpour, Ida, Mojahed, maryam, DANESHI, SAJAD, TANIDEH, NADER, & Jamshidi, Mahshid. (2019). Evaluation of the healing effect of Psidium Guajava L. hydro-alcoholic fruit extract on induced osteoarthritis in male rats. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, 17(3 (66) ), 116-125. SID. https://sid.ir/paper/398360/en

Vancouver: Copy

Nabavizadeh Sara Sadat, Ahmadi Zarei Mohsen, Iraji Cambyz, IRAJI AIDA, GHAEMMAGHAMI PARVIN, KOOHI HOSSEINABADI OMID, Hasssanpour Ida, Mojahed maryam, DANESHI SAJAD, TANIDEH NADER, Jamshidi Mahshid. Evaluation of the healing effect of Psidium Guajava L. hydro-alcoholic fruit extract on induced osteoarthritis in male rats. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY[Internet]. 2019;17(3 (66) ):116-125. Available from: https://sid.ir/paper/398360/en

IEEE: Copy

Sara Sadat Nabavizadeh, Mohsen Ahmadi Zarei, Cambyz Iraji, AIDA IRAJI, PARVIN GHAEMMAGHAMI, OMID KOOHI HOSSEINABADI, Ida Hasssanpour, maryam Mojahed, SAJAD DANESHI, NADER TANIDEH, and Mahshid Jamshidi, “Evaluation of the healing effect of Psidium Guajava L. hydro-alcoholic fruit extract on induced osteoarthritis in male rats,” IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, vol. 17, no. 3 (66) , pp. 116–125, 2019, [Online]. Available: https://sid.ir/paper/398360/en

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