Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats

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TANSAZ MOJGAN; BAHMAN MARYAM; KHODADOOST MAHMOUD; KHODADOOST MAHMOUD; ATHARI SEYYED SHAMSADIN; Ghafarzadeh Saadat; Kashafroodi Hanieh; CHOOPANI RASOOL

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2021 | Volume:23 | Issue:12 Page(s): 13-24

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Title

Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats

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Keywords

Compound honey syrupQ1

Metabolic SyndromeQ1

Polycystic ovary syndromeQ1

Traditional Persian MedicineQ1

Abstract

Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. This study was performed with aim to evaluate the effect of Compound honey syrup on the Polycystic ovary syndrome induced by estradiol valerate in female rats. Methods: In this experimental study conducted by traditional medicine and matria medica research center of Shahid Beheshti University of Medical Sciences in animal laboratory of Shahid Beheshti University of Medical Sciences on female rats in 2017, the Compound honey syrup (Ma-ol-asal) (containing honey, cinnamon, ginger, saffron, cardamom, galangal, nutmeg, mace and mastic) was used. Thirty female rats were classified into five groups of cases: negative control, positive control, and three treatment groups (receiving two doses of Compound honey syrup (1ml/kg and 2ml/kg) and metformin). Polycystic ovary syndrome was induced by injection of Estradiol valerate. At the end of intervention, the rats were euthanized, hormones were measured, and the ovarian histology was examined. Data were analyzed by SPSS software (version 24) and Kruskal-Wallis and Dunn-Bonferroni tests. p < 0. 05 was considered statistically significant. Results: At the end of the study, weights of ovaries in the metformin and Ma-ol-asal 2 groups were higher than the untreated group. There was no change in body weight or abdominal fat. There was a significant increase in levels of progesterone in three treatment groups (P=0. 002) and significant reduction of estrogen in the metformin group compared to the untreated group (P=0. 021). There was significant reduction of number of ovary cysts in Ma-ol-asal 1 group (P=0. 001), and significant increase in the number of Corpus luteum, and antral follicles in Ma-ol-asal 1 and 2 groups compared to the untreated group (P=0. 010). The number of graph follicles did not differ significantly in the groups (P=0. 083). Conclusion: Compound honey syrup was effective in improving hormonal and histological status in Polycystic ovary syndrome as much as metformin and was more effective in some cases.

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APA: Copy

TANSAZ, MOJGAN, BAHMAN, MARYAM, KHODADOOST, MAHMOUD, ATHARI, SEYYED SHAMSADIN, Ghafarzadeh, Saadat, Kashafroodi, Hanieh, & CHOOPANI, RASOOL. (2021). Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 23(12 ), 13-24. SID. https://sid.ir/paper/398713/en

Vancouver: Copy

TANSAZ MOJGAN, BAHMAN MARYAM, KHODADOOST MAHMOUD, ATHARI SEYYED SHAMSADIN, Ghafarzadeh Saadat, Kashafroodi Hanieh, CHOOPANI RASOOL. Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2021;23(12 ):13-24. Available from: https://sid.ir/paper/398713/en

IEEE: Copy

MOJGAN TANSAZ, MARYAM BAHMAN, MAHMOUD KHODADOOST, SEYYED SHAMSADIN ATHARI, Saadat Ghafarzadeh, Hanieh Kashafroodi, and RASOOL CHOOPANI, “Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 23, no. 12 , pp. 13–24, 2021, [Online]. Available: https://sid.ir/paper/398713/en

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