EFFECTS OF CREATINE SUPPLEMENTATION ON LEARNING, MEMORY AND APOPTOSIS AFTER AMYLOID BETA INJECTION IN MALE WISTAR RATS

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ALIMOHAMMADI M.; PISHVA H.; ESHRAGHIAN M.R.; ZARINDAST M.R.

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Journal: Iranian Journal of Nutrition Sciences and Food Technology Year:2015 | Volume:10 | Issue:2 Page(s): 1-10

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Title

EFFECTS OF CREATINE SUPPLEMENTATION ON LEARNING, MEMORY AND APOPTOSIS AFTER AMYLOID BETA INJECTION IN MALE WISTAR RATS

Author(s)

ALIMOHAMMADI M. | PISHVA H. | ESHRAGHIAN M.R. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

ALZHEIMERQ2

CREATINE SUPPLEMENTATIONQ2

LEARNINGQ2

MEMORYQ2

APOPTOSISQ2

Abstract

Background and Objectives: Considering the positive effects of creatine supplement on cognitive performance in healthy individuals, the present study was performed with the aim of determining the effects of CREATINE SUPPLEMENTATION on LEARNING, MEMORY andapoptosis after injection of Amyloid b (Ab) in male wistar rats.Materials & Methods: Twenty four male wistar rats (weighting 250±50 grams) were randomly divided into three groups (n=8 for each groups). Two groups were given a bilateral amyloid beta injection in the CA1 hippocampus (2mg per CA1), one of them received acho containing 2% creatine monohydrate (AdCr+group) and other group continued to receive normal cho (AdCr-). The sham group were injected by normal saline in CA1 hippocampus and received normal cho during the study. After six weeks, the Morris Water Maze (MWM) and Y-maze tests were administered, and LEARNING ability and MEMORY retrieval were measured. After scarification of the animals, TUNEL test for an anti-apoptosis assay was performed.Results: The sham group performed better in Y-maze and MWM compare to the AdCr- and AdCr+ groups. The apoptotic neurons count in the sham group were less than in the AdCr+and AdCr- groups; however, the results indicated no differences between the AdCr+ and AdCr- groups in LEARNING, MEMORY retrieval, and percentage of TUNEL positive neurons.Conclusion: After Ab injection, CREATINE SUPPLEMENTATION had no effect on LEARNING, MEMORY and APOPTOSIS in male wistar rats.

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APA: Copy

ALIMOHAMMADI, M., PISHVA, H., ESHRAGHIAN, M.R., & ZARINDAST, M.R.. (2015). EFFECTS OF CREATINE SUPPLEMENTATION ON LEARNING, MEMORY AND APOPTOSIS AFTER AMYLOID BETA INJECTION IN MALE WISTAR RATS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 10(2), 1-10. SID. https://sid.ir/paper/398854/en

Vancouver: Copy

ALIMOHAMMADI M., PISHVA H., ESHRAGHIAN M.R., ZARINDAST M.R.. EFFECTS OF CREATINE SUPPLEMENTATION ON LEARNING, MEMORY AND APOPTOSIS AFTER AMYLOID BETA INJECTION IN MALE WISTAR RATS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2015;10(2):1-10. Available from: https://sid.ir/paper/398854/en

IEEE: Copy

M. ALIMOHAMMADI, H. PISHVA, M.R. ESHRAGHIAN, and M.R. ZARINDAST, “EFFECTS OF CREATINE SUPPLEMENTATION ON LEARNING, MEMORY AND APOPTOSIS AFTER AMYLOID BETA INJECTION IN MALE WISTAR RATS,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 10, no. 2, pp. 1–10, 2015, [Online]. Available: https://sid.ir/paper/398854/en

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