Comparing the effects of Premedication with Dexmedetomidine, Remifentanil, and Labetalol before Electroconvulsive Therapy on Hemodynamic Responses and Seizure Duration in Psychotic Patients

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Bahramsari Sina; Modir Hesamaldin; MOSHIRI ESMAEIL; JAMILIAN HAMIDREZA; Mohammadbaygi Abolfazl

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2019 | Volume:42 | Issue:3 (107) Page(s): 29-39

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Title

Comparing the effects of Premedication with Dexmedetomidine, Remifentanil, and Labetalol before Electroconvulsive Therapy on Hemodynamic Responses and Seizure Duration in Psychotic Patients

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DexmedetomidineQ1

Electroconvulsive therapyQ1

Hemodynamic responsesQ1

LabetalolQ1

PremedicationQ2

RemifentanilQ2

Abstract

Introduction: The study addressed the comparable effects of Premedication with Dexmedetomidine, Remifentanil and Labetalol before Electroconvulsive therapy (ECT) on Hemodynamic responses and seizure duration in psychotic patients. Materials and methods: A double-blinded trial recruited four randomized groups of patients undergoing ECT (N=144): the DEX, LAB, REM, and NS, receiving 0. 5 μ g/kg Dexmedetomidine and 0. 2 mg/kg Labetalol, 1 μ g/kg Remifentanil, and 20 ml normal saline, respectively, whose mean arterial pressure (MAP), HR, and SPO2 were recorded every 5 minutes until the patient was transferred to the department. Besides, the recovery time, seizure duration, and satisfaction were recorded, afterward followed by SPSS [20] data analysis. Results: BP/HR were lower in the DEX (p=0. 0001) with the longest recovery time (p=0. 0001), while the time was lower in the REM. The first group showed shorter seizure duration, lower selected energy (p=0. 0001), and the highest satisfaction (p=0. 0001) Conclusion: Dexmedetomidine with high patient satisfaction and no need for hemodynamic abnormalities requiring treatment can be a viable option in patients undergoing Electroconvulsive therapy, although it may slightly increase recovery time, and Remifentanil is also a good option for induction of ECT. Patients' satisfaction with it is second only to Dexmedetomidine, and our study did not produce a hemodynamic disorder requiring treatment. Therefore, we believe that either of these drugs may be a good option for use in ECT, depending on the diagnosis of the anesthesiologist.

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APA: Copy

Bahramsari, Sina, Modir, Hesamaldin, MOSHIRI, ESMAEIL, JAMILIAN, HAMIDREZA, & Mohammadbaygi, Abolfazl. (2019). Comparing the effects of Premedication with Dexmedetomidine, Remifentanil, and Labetalol before Electroconvulsive Therapy on Hemodynamic Responses and Seizure Duration in Psychotic Patients. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 42(3 (107) ), 29-39. SID. https://sid.ir/paper/399040/en

Vancouver: Copy

Bahramsari Sina, Modir Hesamaldin, MOSHIRI ESMAEIL, JAMILIAN HAMIDREZA, Mohammadbaygi Abolfazl. Comparing the effects of Premedication with Dexmedetomidine, Remifentanil, and Labetalol before Electroconvulsive Therapy on Hemodynamic Responses and Seizure Duration in Psychotic Patients. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2019;42(3 (107) ):29-39. Available from: https://sid.ir/paper/399040/en

IEEE: Copy

Sina Bahramsari, Hesamaldin Modir, ESMAEIL MOSHIRI, HAMIDREZA JAMILIAN, and Abolfazl Mohammadbaygi, “Comparing the effects of Premedication with Dexmedetomidine, Remifentanil, and Labetalol before Electroconvulsive Therapy on Hemodynamic Responses and Seizure Duration in Psychotic Patients,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 42, no. 3 (107) , pp. 29–39, 2019, [Online]. Available: https://sid.ir/paper/399040/en

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