Effects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

sajadian Seyed mostafa; TEIMOURI MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2020 | Volume:22 | Issue:3 (79) Page(s): 542-549

Download Full-Text

Persian Verion

View:

313

Download:

Cites:

Information Journal Paper

Title

Effects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus

Author(s)

sajadian Seyed mostafa | TEIMOURI MARYAM | Issue Writer Certificate

Keywords

Ziziphora clinopodioidesQ1

Staphylococcus aureusQ2

Efflux pumpQ1

Real-time PCRQ1

Plant ExtractsQ2

Abstract

Introduction: One of the important factors causing nosocomial infections is drug-resistant Staphylococcus aureus strain, so correspondingly, having norA Efflux pump is one of the bacterial's ability to generate drug resistance. Iron has been used as a nanoparticle with antimicrobial activity against bacteria. The aim of this study was to investigate the effect of iron oxide nanoparticles synthesized from ziziphora plant extract on Staphylococcus aureus Efflux pump genes expression. Materials and Methods: green iron nanoparticles were formed using ethanolic extract of ziziphora plant and iron salt solution and identified by SEM and TEM electron microscopy. The Staphylococcus aureus strains were collected and isolated from hospitals and laboratories in Tehran. Considerably, Antimicrobial activity of green nanoparticles against strains was investigated. DNA and RNA and cDNA were extracted and the relative expression of norA gene in Staphylococcus aureus isolates was evaluated by Real-time PCR method. Results: Different strains, under the influence of iron nanoparticles, showed different expression changes That were statistically significant compared to gmk gene expression (P<0. 05). The level of norA gene expression in different strains showed a significant decrease, which indicates the anti-pumping activity of Efflux pump plant extract. Conclusion: the iron oxide nanoparticles synthesized from ziziphora plant extract act as an inhibitor of Efflux pump in Staphylococcus aureus isolates and have potential for use in pharmaceutical and biological industry.

Cites

No record.

References

No record.

Cite

APA: Copy

sajadian, Seyed mostafa, & TEIMOURI, MARYAM. (2020). Effects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus. KOOMESH, 22(3 (79) ), 542-549. SID. https://sid.ir/paper/400791/en

Vancouver: Copy

sajadian Seyed mostafa, TEIMOURI MARYAM. Effects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus. KOOMESH[Internet]. 2020;22(3 (79) ):542-549. Available from: https://sid.ir/paper/400791/en

IEEE: Copy

Seyed mostafa sajadian, and MARYAM TEIMOURI, “Effects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus,” KOOMESH, vol. 22, no. 3 (79) , pp. 542–549, 2020, [Online]. Available: https://sid.ir/paper/400791/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops