THE EFFECT OF CHRONIC CARNOSINE TREATMENT ON SERUM LEVELS OF GLUCOSE AND LIPIDS AND BLOOD PRESSURE IN AN EXPERIMENTAL MODEL OF HYPERLIPIDEMIA IN MICE

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FALLAHI FARAMARZ; ROGHANI MEHRDAD; AHMADI ZAHRA

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Journal: DANESHVAR MEDICINE Year:2012 | Volume:20 | Issue:102 Page(s): 0-0

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Title

THE EFFECT OF CHRONIC CARNOSINE TREATMENT ON SERUM LEVELS OF GLUCOSE AND LIPIDS AND BLOOD PRESSURE IN AN EXPERIMENTAL MODEL OF HYPERLIPIDEMIA IN MICE

Author(s)

FALLAHI FARAMARZ | ROGHANI MEHRDAD | AHMADI ZAHRA | Issue Writer Certificate

Keywords

CARNOSINEQ2

HYPERLIPIDEMIAQ3

DYSLIPIDEMIAQ3

GLUCOSEQ2

SYSTOLIC BLOOD PRESSUREQ3

Abstract

Background and Objective: Chronic HYPERLIPIDEMIA accompanies various complications in the body. With regard to protective and beneficial effect of CARNOSINE in metabolic disorders, this study was conducted to evaluate its effect on serum lipids and blood pressure in an experimental model of HYPERLIPIDEMIA in mice.Materials and Methods: Mice were divided into five groups, i.e. control, high-dose CARNOSINE-treated control, hyperlipidemic, and two CARNOSINE-treated (125 and 250 mg/kg) hyperlipidemic groups. CARNOSINE was administered i.p. from 8th week after HYPERLIPIDEMIA induction for 4 weeks.Results: CARNOSINE did not cause any significant reduction of serum GLUCOSE, there was a significant increase in serum total cholesterol and triglyceride in hyperlipidemic group as compared to control (p<0.05-0.01) and CARNOSINE at a high dose significantly decreased it (p<0.05).Regarding serum HDL cholesterol, CARNOSINE treatment did not significantly change it. In contrast, HYPERLIPIDEMIA significantly increased LDL-cholesterol (p<0.05) and CARNOSINE at a dose of 250 mg/kg significantly lowered it (p<0.05). In addition, hyperlipidemic mice has a significantly higher SYSTOLIC BLOOD PRESSURE (p<0.05) and CARNOSINE treatment did not significantly change it.Conclusion: Administration of CARNOSINE to hyperlipidemic mice does not affect serum GLUCOSE level and SYSTOLIC BLOOD PRESSURE and significantly lowers serum total cholesterol, LDL-cholesterol, and triglyceride level.

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APA: Copy

FALLAHI, FARAMARZ, ROGHANI, MEHRDAD, & AHMADI, ZAHRA. (2012). THE EFFECT OF CHRONIC CARNOSINE TREATMENT ON SERUM LEVELS OF GLUCOSE AND LIPIDS AND BLOOD PRESSURE IN AN EXPERIMENTAL MODEL OF HYPERLIPIDEMIA IN MICE. DANESHVAR MEDICINE, 20(102), 0-0. SID. https://sid.ir/paper/401347/en

Vancouver: Copy

FALLAHI FARAMARZ, ROGHANI MEHRDAD, AHMADI ZAHRA. THE EFFECT OF CHRONIC CARNOSINE TREATMENT ON SERUM LEVELS OF GLUCOSE AND LIPIDS AND BLOOD PRESSURE IN AN EXPERIMENTAL MODEL OF HYPERLIPIDEMIA IN MICE. DANESHVAR MEDICINE[Internet]. 2012;20(102):0-0. Available from: https://sid.ir/paper/401347/en

IEEE: Copy

FARAMARZ FALLAHI, MEHRDAD ROGHANI, and ZAHRA AHMADI, “THE EFFECT OF CHRONIC CARNOSINE TREATMENT ON SERUM LEVELS OF GLUCOSE AND LIPIDS AND BLOOD PRESSURE IN AN EXPERIMENTAL MODEL OF HYPERLIPIDEMIA IN MICE,” DANESHVAR MEDICINE, vol. 20, no. 102, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/401347/en

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