EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON RIGIDITY OF ANIMAL MODEL OF PARKINSON'S DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAFIEI ARDESTANI M.; FATHI MOGHADAM H.; HEMATI A.A.; NAZARI ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2008 | Volume:66 | Issue:5 Page(s): 299-304

Download Full-Text

Persian Verion

View:

3,271

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON RIGIDITY OF ANIMAL MODEL OF PARKINSON'S DISEASE

Author(s)

SHAFIEI ARDESTANI M. | FATHI MOGHADAM H. | HEMATI A.A. | NAZARI ZAHRA | Issue Writer Certificate

Keywords

PARKINSON’S DISEASEQ3

CYCLOOXYGENASE-2Q3

CELECOXIBQ3

ASPIRINQ3

Abstract

Background: Parkinson's disease (PD) is a degenerative neurodopaminergic disease in nigrostriatum pathway of animals and human, the resultant loss of nerve terminals accompanied by dopamine-glutamate and other related neurotransmitters-imbalances in this pathway are responsible for most of the movement abnormalities. Increasing evidence suggests that an inflammatory reaction accompanies the pathological processes caused by CYCLOOXYGENASE-2 (COX-2) seen in many neurodegenerative disorders, including PD. These findings have not indicated any evidence based on the effect of selective and non selective COX-2 inhibitors on the rigidity of PD.Methods: The rats left substantia nigra pars compacta (SNc) was destroyed using the electrical lesion thus PD model was created. Then oral ASPIRIN and CELECOXIB (200, 400 mg/kg) were administrated to parkinsonian rats acutely and then the rigidity was evaluated using Murprogo’s Method.Results: Both compounds were able to decrease the rigidity of parkinsonian rats (p<0.05) respectively but selective cox-2 inhibitor (celecoxib) was found more effective and potent than that of non selective cox-2 inhibitor (aspirin).Conclusion: The findings suggest that COX-2 inhibition decreases the rigidity of PD in the animal model. Therefore, as results of the study COX-2 inhibition was shown good evidence based on the use of ASPIRIN and CELECOXIB and PD affiliated rigidity improvement that this can be beneficial and interest for neuroscientists. These findings are additional pharmacological and medicinal information to further assess of non steroidal anti inflammatory drugs (NSAIDs) as alternative therapeutic agents for PD affiliated rigidity treatment. Further experiments seem to be necessary to complete this research such as investigation the effects of NSAIDs on the striatum neurotransmission pathway.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAFIEI ARDESTANI, M., FATHI MOGHADAM, H., HEMATI, A.A., & NAZARI, ZAHRA. (2008). EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON RIGIDITY OF ANIMAL MODEL OF PARKINSON'S DISEASE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(5), 299-304. SID. https://sid.ir/paper/401949/en

Vancouver: Copy

SHAFIEI ARDESTANI M., FATHI MOGHADAM H., HEMATI A.A., NAZARI ZAHRA. EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON RIGIDITY OF ANIMAL MODEL OF PARKINSON'S DISEASE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2008;66(5):299-304. Available from: https://sid.ir/paper/401949/en

IEEE: Copy

M. SHAFIEI ARDESTANI, H. FATHI MOGHADAM, A.A. HEMATI, and ZAHRA NAZARI, “EFFECT OF CYCLOOXYGENASE-2 INHIBITION ON RIGIDITY OF ANIMAL MODEL OF PARKINSON'S DISEASE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 5, pp. 299–304, 2008, [Online]. Available: https://sid.ir/paper/401949/en

Related Journal Papers