SURVEY THE SINGLE NUCLEOTIDE POLYMORPHISM OF TGFBETA AT CODON 25 IN TYPE 1 DIABETIC PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MASOUD MAHTAB; SALEHI I.; SHEYKH BAHAEI N.; RAJAB ASAD ELAH; VOJGANI M.; MASOUD A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:16 | Issue:62 Page(s): 1-6

Download Full-Text

Persian Verion

View:

765

Download:

Cites:

Information Journal Paper

Title

SURVEY THE SINGLE NUCLEOTIDE POLYMORPHISM OF TGFBETA AT CODON 25 IN TYPE 1 DIABETIC PATIENTS

Author(s)

Keywords

DIABETES MELLITUSQ3

INSULIN – DEPENDENTQ3

NUCLEOTIDESQ3

TRANSFORMING GROWTH FACTOR BETAQ3

Abstract

Introduction: Type 1 diabetes is an autoimmune disease which is characterized by T-cell mediated destruction of pancreatic β-cells. A variety of environmental and genetic factors are involved in the development of the disease.Transforming Growth Factor Beta-1 (TGFb) is a multifunctional cytokine that affected regulation and difference of immune responses and there is abnormal secretion of this auto immune disease.Genetic polymorphisms in the TGFb gene influenced production and secretion of cytokine and figured as a risk factor in auto immune disease.Objective: In this study, single nucleotide polymorphism of TGFb at codon 25 is investigated in type 1 diabetic patients and compared with healthy controls.Materials and Methods: This was a case control study which 75 type 1 diabetic patients who had definitely diagnosed at least 2 years before sampling and were under Insulin therapy were selected. Control group were selected from voluntarily blood donors who had referred to IRAN Blood Transfusion Organization.Data were analyzed by SPSS and using chi- square test with 95% confidence interval.Results: The findings showed that there were not statistically significant differences in GC polymorphism at +915 between cases and control groups (p value 0.05).Conclusion Although TGFb polymorphism at +915 regions affects the production of cytokine regulates immune responses; this study showed that single nucleotide polymorphism in this region can not be involved in onset of type 1diabetes and can not be considered as risk factor.

Cites

THE STUDY OF ASSOCIATION BETWEEN TGF-B1 GENE 915 G>C POLYMORPHISMS AND CHRONIC HEPATITIS C INFECTION

References

No record.

Cite

APA: Copy

MASOUD, MAHTAB, SALEHI, I., SHEYKH BAHAEI, N., RAJAB, ASAD ELAH, VOJGANI, M., & MASOUD, A.. (2007). SURVEY THE SINGLE NUCLEOTIDE POLYMORPHISM OF TGFBETA AT CODON 25 IN TYPE 1 DIABETIC PATIENTS. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 16(62), 1-6. SID. https://sid.ir/paper/40222/en

Vancouver: Copy

MASOUD MAHTAB, SALEHI I., SHEYKH BAHAEI N., RAJAB ASAD ELAH, VOJGANI M., MASOUD A.. SURVEY THE SINGLE NUCLEOTIDE POLYMORPHISM OF TGFBETA AT CODON 25 IN TYPE 1 DIABETIC PATIENTS. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;16(62):1-6. Available from: https://sid.ir/paper/40222/en

IEEE: Copy

MAHTAB MASOUD, I. SALEHI, N. SHEYKH BAHAEI, ASAD ELAH RAJAB, M. VOJGANI, and A. MASOUD, “SURVEY THE SINGLE NUCLEOTIDE POLYMORPHISM OF TGFBETA AT CODON 25 IN TYPE 1 DIABETIC PATIENTS,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 62, pp. 1–6, 2007, [Online]. Available: https://sid.ir/paper/40222/en

Related Journal Papers